Un caso di post Kala-azar dermal leishmaniasis nell'area del mediterraneo

Translated title of the contribution: Post Kala-azar leishmaniasis (PKDL) in the Mediterranean area

G. Pianosi, R. Simoni, G. Annessi, L. Gradoni

Research output: Contribution to journalArticle

Abstract

The first case of Post Kala-azar dermal leishmaniasis (PKDT) in a 40-year-old man living in central Italy with no history of foreign travel. He came to us in June '95 with diffuse bright red oval nodules and papules. On his face he had bright red plaques. These lesions appeared one year after a cure for visceral leishmaniasis (VL), caused by Leishmania infantum. Lab. results: Thrombocytopenia (105,000/mm3), polyclonal hypergammaglobulineamia (17.7 g/L), increased ESR, VDRL, TPHA and Lupus band test all neg., speckled ANA 1/80. Decreased in CD4+ T-lymphocyte count 3 not correlated with immunodeficiency and ELISA + Western blot for HIV repeatedly negative suggesting a probable idiopathic CD4+ T-lymphocytopenia. Histology: diffuse infiltrates mostly perivascular lymphocytes, plasma cells and histiocytes, present in the superficial and mid-derma, containing leishmania amastigotes. Parasitology: positive skin culture on Tobie modified Evans medium, bone marrow aspirate neg. but culture showed leishmania development. Parasite characterisation revealed Leishmania infantum. Clinical and laboratory findings indicated PKDL, a disease frequently found in India and Africa, as a dermatological complication of VL, caused by Leishmania donovani. The patient was cured by a high intermittent dose of liposomal amphotericin B (AmBisome).

Original languageItalian
Pages (from-to)65-73
Number of pages9
JournalChronica Dermatologica
Volume6
Issue number6 SUPPL.
Publication statusPublished - 1996

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Leishmaniasis
Visceral Leishmaniasis
Leishmania infantum
Leishmania
Idiopathic CD4 Positive T-Lymphocytopenia
Leishmania donovani
Parasitology
Skin
Histiocytes
CD4 Lymphocyte Count
Plasma Cells
Thrombocytopenia
Italy
India
Histology
Parasites
Bone Marrow
Western Blotting
Enzyme-Linked Immunosorbent Assay
HIV

ASJC Scopus subject areas

  • Dermatology

Cite this

Un caso di post Kala-azar dermal leishmaniasis nell'area del mediterraneo. / Pianosi, G.; Simoni, R.; Annessi, G.; Gradoni, L.

In: Chronica Dermatologica, Vol. 6, No. 6 SUPPL., 1996, p. 65-73.

Research output: Contribution to journalArticle

Pianosi, G, Simoni, R, Annessi, G & Gradoni, L 1996, 'Un caso di post Kala-azar dermal leishmaniasis nell'area del mediterraneo', Chronica Dermatologica, vol. 6, no. 6 SUPPL., pp. 65-73.
Pianosi, G. ; Simoni, R. ; Annessi, G. ; Gradoni, L. / Un caso di post Kala-azar dermal leishmaniasis nell'area del mediterraneo. In: Chronica Dermatologica. 1996 ; Vol. 6, No. 6 SUPPL. pp. 65-73.
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