Post-liver transplant intrahepatic cholestasis: etiology, clinical presentation, therapy

F R Ponziani, S Bhoori, M Pompili, M A Zocco, M Biolato, G Marrone, A Gasbarrini, V Mazzaferro, A Grieco

Research output: Contribution to journalArticle

Abstract

Post-liver transplant intrahepatic cholestasis is consequent to the impairment of bile flow or formation. It may develop in the early (within 6 months) or in the late (more than 6 months) post-liver transplant period and different causes may be recognized according to the time elapsed from a liver transplant. The raise at various degrees of serum bilirubin, alkaline phosphatase, and gamma-glutamyl transpeptidase, with or without increased transaminases levels, are common hematochemical findings. Liver histology is helpful for diagnostic assessment, and sometimes crucial to differentiate among possible causes of cholestasis. Although timely treatment of underling conditions as well as supportive care may resolve post-liver transplant intrahepatic cholestasis, the risk of graft loss and retransplantation are remarkable. For this reason, post-liver transplant intrahepatic cholestasis should be managed in collaboration with the LT center, and treatment should be devolved to expert hepatologists.

Original languageEnglish
Pages (from-to)23-36
Number of pages14
JournalEuropean Review for Medical and Pharmacological Sciences
Volume21
Issue number1 Suppl
Publication statusPublished - Mar 2017

Keywords

  • Cholestasis, Intrahepatic
  • Humans
  • Liver Transplantation
  • Reoperation
  • gamma-Glutamyltransferase
  • Journal Article

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