Post-menopausal hormonal therapy and gallbladder cancer risk

Silvano Gallus, Eva Negri, Liliane Chatenoud, Cristina Bosetti, Silvia Franceschi, Carlo La Vecchia

Research output: Contribution to journalArticlepeer-review


The relation between post-menopausal hormone replacement therapy (HRT) and gallbladder cancer was analyzed in women above age 45 years, using data of a case-control study conducted in Italy between 1985 and 1997, on 31 incident, histologically confirmed cases and 3,702 controls in hospital for acute, non-neoplastic conditions. The multivariate odds ratio (OR) was 3.2 (95% confidence interval: 1.1-9.3) for those who had ever used HRT and the OR tended to rise with longer duration. Although based on small numbers, due to the rarity of the disease, these findings provide the first direct epidemiological evidence of an association between HRT and gallbladder cancer.

Original languageEnglish
Pages (from-to)762-763
Number of pages2
JournalInternational Journal of Cancer
Issue number5
Publication statusPublished - 2002


  • Case-control studies
  • Gallbladder cancer
  • Hormonal replacement therapy
  • Risk factors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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