Post-stroke depression increases disability more than 15% in ischemic stroke survivors: A case-control study

Stefano Paolucci, Marco Iosa, Paola Coiro, Vincenzo Venturiero, Anna Savo, Domenico De Angelis, Giovanni Morone

Research output: Contribution to journalArticle

Abstract

We performed a retrospective, case-control study in consecutive ischemic stroke patients admitted to our stroke rehabilitation unit. Patients were matched for severity of neurological impairment (evaluated with the Canadian Neurological Scale, CNS), age (difference within 1 year), and onset admission interval (difference within 3 days). Participants were divided into two subgroups according to the presence or absence of PSD. Aim was to assess the specific influence of post-stroke depression (PSD) and antidepressant treatment on both basal functional status and rehabilitation outcomes. All PSD patients were treated primarily with serotoninergic antidepressants (AD). The final sample included 280 patients with depression (out of 320 found in a whole case series of 993 ischemic patients, i.e., 32.25%) and 280 without depression. Forty patients with depression were excluded because they had a history of severe psychiatric illness or aphasia, with a severe comprehension deficit. On one hand, PSD patients obtained lower Barthel Index (BI) and Rivermead Mobility Index (RMI) scores at both admission and discharge, with minor effectiveness of rehabilitative treatment and longer length of stay; on the other hand, this group had a lower percentage of dropouts. Lastly, PSD patients showed a different functional outcome, based on their response to antidepressant therapy, that was significantly better in responders than in non-responders (13.13%). Our results confirm the unfavorable influence of PSD on functional outcome, despite pharmacological treatment.

Original languageEnglish
Article number926
JournalFrontiers in Neurology
Volume10
Issue numberAUG
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Survivors
Case-Control Studies
Stroke
Depression
Antidepressive Agents
Aphasia
Psychiatry
Length of Stay
Therapeutics
Pharmacology

Keywords

  • Antidepressants
  • Depression
  • Functional outcome
  • Rehabilitation
  • Stroke

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Post-stroke depression increases disability more than 15% in ischemic stroke survivors : A case-control study. / Paolucci, Stefano; Iosa, Marco; Coiro, Paola; Venturiero, Vincenzo; Savo, Anna; De Angelis, Domenico; Morone, Giovanni.

In: Frontiers in Neurology, Vol. 10, No. AUG, 926, 01.01.2019.

Research output: Contribution to journalArticle

@article{4dd259173ffb410d9e162d191051d480,
title = "Post-stroke depression increases disability more than 15{\%} in ischemic stroke survivors: A case-control study",
abstract = "We performed a retrospective, case-control study in consecutive ischemic stroke patients admitted to our stroke rehabilitation unit. Patients were matched for severity of neurological impairment (evaluated with the Canadian Neurological Scale, CNS), age (difference within 1 year), and onset admission interval (difference within 3 days). Participants were divided into two subgroups according to the presence or absence of PSD. Aim was to assess the specific influence of post-stroke depression (PSD) and antidepressant treatment on both basal functional status and rehabilitation outcomes. All PSD patients were treated primarily with serotoninergic antidepressants (AD). The final sample included 280 patients with depression (out of 320 found in a whole case series of 993 ischemic patients, i.e., 32.25{\%}) and 280 without depression. Forty patients with depression were excluded because they had a history of severe psychiatric illness or aphasia, with a severe comprehension deficit. On one hand, PSD patients obtained lower Barthel Index (BI) and Rivermead Mobility Index (RMI) scores at both admission and discharge, with minor effectiveness of rehabilitative treatment and longer length of stay; on the other hand, this group had a lower percentage of dropouts. Lastly, PSD patients showed a different functional outcome, based on their response to antidepressant therapy, that was significantly better in responders than in non-responders (13.13{\%}). Our results confirm the unfavorable influence of PSD on functional outcome, despite pharmacological treatment.",
keywords = "Antidepressants, Depression, Functional outcome, Rehabilitation, Stroke",
author = "Stefano Paolucci and Marco Iosa and Paola Coiro and Vincenzo Venturiero and Anna Savo and {De Angelis}, Domenico and Giovanni Morone",
year = "2019",
month = "1",
day = "1",
doi = "10.3389/fneur.2019.00926",
language = "English",
volume = "10",
journal = "Frontiers in Neurology",
issn = "1664-2295",
publisher = "Frontiers Research Foundation",
number = "AUG",

}

TY - JOUR

T1 - Post-stroke depression increases disability more than 15% in ischemic stroke survivors

T2 - A case-control study

AU - Paolucci, Stefano

AU - Iosa, Marco

AU - Coiro, Paola

AU - Venturiero, Vincenzo

AU - Savo, Anna

AU - De Angelis, Domenico

AU - Morone, Giovanni

PY - 2019/1/1

Y1 - 2019/1/1

N2 - We performed a retrospective, case-control study in consecutive ischemic stroke patients admitted to our stroke rehabilitation unit. Patients were matched for severity of neurological impairment (evaluated with the Canadian Neurological Scale, CNS), age (difference within 1 year), and onset admission interval (difference within 3 days). Participants were divided into two subgroups according to the presence or absence of PSD. Aim was to assess the specific influence of post-stroke depression (PSD) and antidepressant treatment on both basal functional status and rehabilitation outcomes. All PSD patients were treated primarily with serotoninergic antidepressants (AD). The final sample included 280 patients with depression (out of 320 found in a whole case series of 993 ischemic patients, i.e., 32.25%) and 280 without depression. Forty patients with depression were excluded because they had a history of severe psychiatric illness or aphasia, with a severe comprehension deficit. On one hand, PSD patients obtained lower Barthel Index (BI) and Rivermead Mobility Index (RMI) scores at both admission and discharge, with minor effectiveness of rehabilitative treatment and longer length of stay; on the other hand, this group had a lower percentage of dropouts. Lastly, PSD patients showed a different functional outcome, based on their response to antidepressant therapy, that was significantly better in responders than in non-responders (13.13%). Our results confirm the unfavorable influence of PSD on functional outcome, despite pharmacological treatment.

AB - We performed a retrospective, case-control study in consecutive ischemic stroke patients admitted to our stroke rehabilitation unit. Patients were matched for severity of neurological impairment (evaluated with the Canadian Neurological Scale, CNS), age (difference within 1 year), and onset admission interval (difference within 3 days). Participants were divided into two subgroups according to the presence or absence of PSD. Aim was to assess the specific influence of post-stroke depression (PSD) and antidepressant treatment on both basal functional status and rehabilitation outcomes. All PSD patients were treated primarily with serotoninergic antidepressants (AD). The final sample included 280 patients with depression (out of 320 found in a whole case series of 993 ischemic patients, i.e., 32.25%) and 280 without depression. Forty patients with depression were excluded because they had a history of severe psychiatric illness or aphasia, with a severe comprehension deficit. On one hand, PSD patients obtained lower Barthel Index (BI) and Rivermead Mobility Index (RMI) scores at both admission and discharge, with minor effectiveness of rehabilitative treatment and longer length of stay; on the other hand, this group had a lower percentage of dropouts. Lastly, PSD patients showed a different functional outcome, based on their response to antidepressant therapy, that was significantly better in responders than in non-responders (13.13%). Our results confirm the unfavorable influence of PSD on functional outcome, despite pharmacological treatment.

KW - Antidepressants

KW - Depression

KW - Functional outcome

KW - Rehabilitation

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=85071766991&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071766991&partnerID=8YFLogxK

U2 - 10.3389/fneur.2019.00926

DO - 10.3389/fneur.2019.00926

M3 - Article

AN - SCOPUS:85071766991

VL - 10

JO - Frontiers in Neurology

JF - Frontiers in Neurology

SN - 1664-2295

IS - AUG

M1 - 926

ER -