Post-stroke depression: Research methodology of a large multicentre observational study (DESTRO)

V. Toso, C. Gandolfo, S. Paolucci, L. Provinciali, R. Torta, N. Grassivaro, G. Lagalla, M. G. Manicone, M. Del Gobbo, S. Paolini, E. Bottacchi, G. Corso, F. Federico, D. Martino, F. Salsa, E. Turinese, M. Gentile, S. Bogo, M. Crisci, T. SacquegnaV. Santamato, G. Pietrarossa, G. Coppola, G. Trianni, G. Pennisi, R. Bella, S. Ricci, K. Amantini, S. Buzzelli, L. Di Francesco, B. Antonelli, G. Pelliccia, E. Paolino, E. Iezzi, P. Nencini, C. Sarti, W. Neri, G. Galletti, S. Pretta, M. Del Sette, E. Giaccaglini, C. Sconocchini, A. Carolei, C. Capannolo, F. A. De Falco, R. Santangelo, R. Musolino, S. Gangemi, R. Vita, R. Di Leo, M. Comola, S. Mammi, M. A. Zamperretti, C. A. Delfanti, S. Sommacal, G. Rudelli, V. Scarano, G. Coppola, M. P. Giordana, R. Sciolla, G. Meneghetti, M. Ottina, A. Ponari, R. Castiglia, D. Mancia, C. Zanferrari, G. Micieli, E. Zambrelli, G. Cardaioli, V. Gallai, R. Badino, T. Tassinari, G. Orlandi, S. Fanucchi, G. Ciucci, G. Padoan, F. Gasparini, D. Guidetti, D. De Angelis, G. A. Amabile, G. Fiermonte Rome, C. Roberti, A. Foti, L. Cainelli, M. Chiusole, S. Pasqualino, D. Intiso, S. Giovanni, M. Tonizzo, A. Basile, S. Vito, P. Viviani, M. L. Stromillo, A. Federico, W. Liboni, E. Pavanelli, B. Bergamasco, P. Cerrato, A. Boghi

Research output: Contribution to journalArticlepeer-review


The heterogeneity of published data regarding post-stroke depression (PSD) prompted an Italian multicenter observational study (DESTRO), which took place in 2000-2003. The investigation involved 53 Italian neurology centers: of these, 50 treat acute patients and 3 provide rehabilitation care; 21 centres are in Northern Italy, 20 are in Central Italy, and 12 are in Southern Italy. The time schedule was articulated into three phases: registration of 6289 stroke patients; selection of 1817 cases and enrolment of 1074 patients; and follow-up for two years (1064 patients). Mood assessment was performed by evaluating depressive symptoms according to DSM IV and the Beck depression inventory (visual analog mood scale for aphasic patients). Depressed patients were also administered the Montgomery-Asberg depression rating scale. Scores were related to function (Barthel index, modified Rankin scale), cognition (MMSE), quality of life (SF-36), and clinical data. Data analysis will provide information on PSD prevalence, onset and evolution, correlation with ischemic clinical syndrome, impact on activities of daily living, cognitive level and quality of life. The few data available at the present time concern PSD prevalence in the first six months after stroke (33.6%). DESTRO is a longitudinal investigation of a large patient sample and is expected to provide insights into the relationship of PDS with the functional and clinical consequences of stroke.

Original languageEnglish
Pages (from-to)138-144
Number of pages7
JournalNeurological Sciences
Issue number3
Publication statusPublished - Jul 2004


  • Depression
  • Outcome
  • Risk factor
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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