Post-stroke depression

Research methodology of a large multicentre observational study (DESTRO)

V. Toso, C. Gandolfo, S. Paolucci, L. Provinciali, R. Torta, N. Grassivaro, G. Lagalla, M. G. Manicone, M. Del Gobbo, S. Paolini, E. Bottacchi, G. Corso, F. Federico, D. Martino, F. Salsa, E. Turinese, M. Gentile, S. Bogo, M. Crisci, T. Sacquegna & 79 others V. Santamato, G. Pietrarossa, G. Coppola, G. Trianni, G. Pennisi, R. Bella, S. Ricci, K. Amantini, S. Buzzelli, L. Di Francesco, B. Antonelli, G. Pelliccia, E. Paolino, E. Iezzi, P. Nencini, C. Sarti, W. Neri, G. Galletti, S. Pretta, M. Del Sette, E. Giaccaglini, C. Sconocchini, A. Carolei, C. Capannolo, F. A. De Falco, R. Santangelo, R. Musolino, S. Gangemi, R. Vita, R. Di Leo, M. Comola, S. Mammi, M. A. Zamperretti, C. A. Delfanti, S. Sommacal, G. Rudelli, V. Scarano, G. Coppola, M. P. Giordana, R. Sciolla, G. Meneghetti, M. Ottina, A. Ponari, R. Castiglia, D. Mancia, C. Zanferrari, G. Micieli, E. Zambrelli, G. Cardaioli, V. Gallai, R. Badino, T. Tassinari, G. Orlandi, S. Fanucchi, G. Ciucci, G. Padoan, F. Gasparini, D. Guidetti, D. De Angelis, G. A. Amabile, G. Fiermonte Rome, C. Roberti, A. Foti, L. Cainelli, M. Chiusole, S. Pasqualino, D. Intiso, S. Giovanni, M. Tonizzo, A. Basile, S. Vito, P. Viviani, M. L. Stromillo, A. Federico, W. Liboni, E. Pavanelli, B. Bergamasco, P. Cerrato, A. Boghi

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The heterogeneity of published data regarding post-stroke depression (PSD) prompted an Italian multicenter observational study (DESTRO), which took place in 2000-2003. The investigation involved 53 Italian neurology centers: of these, 50 treat acute patients and 3 provide rehabilitation care; 21 centres are in Northern Italy, 20 are in Central Italy, and 12 are in Southern Italy. The time schedule was articulated into three phases: registration of 6289 stroke patients; selection of 1817 cases and enrolment of 1074 patients; and follow-up for two years (1064 patients). Mood assessment was performed by evaluating depressive symptoms according to DSM IV and the Beck depression inventory (visual analog mood scale for aphasic patients). Depressed patients were also administered the Montgomery-Asberg depression rating scale. Scores were related to function (Barthel index, modified Rankin scale), cognition (MMSE), quality of life (SF-36), and clinical data. Data analysis will provide information on PSD prevalence, onset and evolution, correlation with ischemic clinical syndrome, impact on activities of daily living, cognitive level and quality of life. The few data available at the present time concern PSD prevalence in the first six months after stroke (33.6%). DESTRO is a longitudinal investigation of a large patient sample and is expected to provide insights into the relationship of PDS with the functional and clinical consequences of stroke.

Original languageEnglish
Pages (from-to)138-144
Number of pages7
JournalNeurological Sciences
Volume25
Issue number3
Publication statusPublished - Jul 2004

Fingerprint

Multicenter Studies
Observational Studies
Research Design
Stroke
Depression
Italy
Quality of Life
Neurology
Activities of Daily Living
Visual Analog Scale
Diagnostic and Statistical Manual of Mental Disorders
Cognition
Appointments and Schedules
Rehabilitation
Equipment and Supplies

Keywords

  • Depression
  • Outcome
  • Risk factor
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Toso, V., Gandolfo, C., Paolucci, S., Provinciali, L., Torta, R., Grassivaro, N., ... Boghi, A. (2004). Post-stroke depression: Research methodology of a large multicentre observational study (DESTRO). Neurological Sciences, 25(3), 138-144.

Post-stroke depression : Research methodology of a large multicentre observational study (DESTRO). / Toso, V.; Gandolfo, C.; Paolucci, S.; Provinciali, L.; Torta, R.; Grassivaro, N.; Lagalla, G.; Manicone, M. G.; Del Gobbo, M.; Paolini, S.; Bottacchi, E.; Corso, G.; Federico, F.; Martino, D.; Salsa, F.; Turinese, E.; Gentile, M.; Bogo, S.; Crisci, M.; Sacquegna, T.; Santamato, V.; Pietrarossa, G.; Coppola, G.; Trianni, G.; Pennisi, G.; Bella, R.; Ricci, S.; Amantini, K.; Buzzelli, S.; Di Francesco, L.; Antonelli, B.; Pelliccia, G.; Paolino, E.; Iezzi, E.; Nencini, P.; Sarti, C.; Neri, W.; Galletti, G.; Pretta, S.; Del Sette, M.; Giaccaglini, E.; Sconocchini, C.; Carolei, A.; Capannolo, C.; De Falco, F. A.; Santangelo, R.; Musolino, R.; Gangemi, S.; Vita, R.; Di Leo, R.; Comola, M.; Mammi, S.; Zamperretti, M. A.; Delfanti, C. A.; Sommacal, S.; Rudelli, G.; Scarano, V.; Coppola, G.; Giordana, M. P.; Sciolla, R.; Meneghetti, G.; Ottina, M.; Ponari, A.; Castiglia, R.; Mancia, D.; Zanferrari, C.; Micieli, G.; Zambrelli, E.; Cardaioli, G.; Gallai, V.; Badino, R.; Tassinari, T.; Orlandi, G.; Fanucchi, S.; Ciucci, G.; Padoan, G.; Gasparini, F.; Guidetti, D.; De Angelis, D.; Amabile, G. A.; Fiermonte Rome, G.; Roberti, C.; Foti, A.; Cainelli, L.; Chiusole, M.; Pasqualino, S.; Intiso, D.; Giovanni, S.; Tonizzo, M.; Basile, A.; Vito, S.; Viviani, P.; Stromillo, M. L.; Federico, A.; Liboni, W.; Pavanelli, E.; Bergamasco, B.; Cerrato, P.; Boghi, A.

In: Neurological Sciences, Vol. 25, No. 3, 07.2004, p. 138-144.

Research output: Contribution to journalArticle

Toso, V, Gandolfo, C, Paolucci, S, Provinciali, L, Torta, R, Grassivaro, N, Lagalla, G, Manicone, MG, Del Gobbo, M, Paolini, S, Bottacchi, E, Corso, G, Federico, F, Martino, D, Salsa, F, Turinese, E, Gentile, M, Bogo, S, Crisci, M, Sacquegna, T, Santamato, V, Pietrarossa, G, Coppola, G, Trianni, G, Pennisi, G, Bella, R, Ricci, S, Amantini, K, Buzzelli, S, Di Francesco, L, Antonelli, B, Pelliccia, G, Paolino, E, Iezzi, E, Nencini, P, Sarti, C, Neri, W, Galletti, G, Pretta, S, Del Sette, M, Giaccaglini, E, Sconocchini, C, Carolei, A, Capannolo, C, De Falco, FA, Santangelo, R, Musolino, R, Gangemi, S, Vita, R, Di Leo, R, Comola, M, Mammi, S, Zamperretti, MA, Delfanti, CA, Sommacal, S, Rudelli, G, Scarano, V, Coppola, G, Giordana, MP, Sciolla, R, Meneghetti, G, Ottina, M, Ponari, A, Castiglia, R, Mancia, D, Zanferrari, C, Micieli, G, Zambrelli, E, Cardaioli, G, Gallai, V, Badino, R, Tassinari, T, Orlandi, G, Fanucchi, S, Ciucci, G, Padoan, G, Gasparini, F, Guidetti, D, De Angelis, D, Amabile, GA, Fiermonte Rome, G, Roberti, C, Foti, A, Cainelli, L, Chiusole, M, Pasqualino, S, Intiso, D, Giovanni, S, Tonizzo, M, Basile, A, Vito, S, Viviani, P, Stromillo, ML, Federico, A, Liboni, W, Pavanelli, E, Bergamasco, B, Cerrato, P & Boghi, A 2004, 'Post-stroke depression: Research methodology of a large multicentre observational study (DESTRO)', Neurological Sciences, vol. 25, no. 3, pp. 138-144.
Toso V, Gandolfo C, Paolucci S, Provinciali L, Torta R, Grassivaro N et al. Post-stroke depression: Research methodology of a large multicentre observational study (DESTRO). Neurological Sciences. 2004 Jul;25(3):138-144.
Toso, V. ; Gandolfo, C. ; Paolucci, S. ; Provinciali, L. ; Torta, R. ; Grassivaro, N. ; Lagalla, G. ; Manicone, M. G. ; Del Gobbo, M. ; Paolini, S. ; Bottacchi, E. ; Corso, G. ; Federico, F. ; Martino, D. ; Salsa, F. ; Turinese, E. ; Gentile, M. ; Bogo, S. ; Crisci, M. ; Sacquegna, T. ; Santamato, V. ; Pietrarossa, G. ; Coppola, G. ; Trianni, G. ; Pennisi, G. ; Bella, R. ; Ricci, S. ; Amantini, K. ; Buzzelli, S. ; Di Francesco, L. ; Antonelli, B. ; Pelliccia, G. ; Paolino, E. ; Iezzi, E. ; Nencini, P. ; Sarti, C. ; Neri, W. ; Galletti, G. ; Pretta, S. ; Del Sette, M. ; Giaccaglini, E. ; Sconocchini, C. ; Carolei, A. ; Capannolo, C. ; De Falco, F. A. ; Santangelo, R. ; Musolino, R. ; Gangemi, S. ; Vita, R. ; Di Leo, R. ; Comola, M. ; Mammi, S. ; Zamperretti, M. A. ; Delfanti, C. A. ; Sommacal, S. ; Rudelli, G. ; Scarano, V. ; Coppola, G. ; Giordana, M. P. ; Sciolla, R. ; Meneghetti, G. ; Ottina, M. ; Ponari, A. ; Castiglia, R. ; Mancia, D. ; Zanferrari, C. ; Micieli, G. ; Zambrelli, E. ; Cardaioli, G. ; Gallai, V. ; Badino, R. ; Tassinari, T. ; Orlandi, G. ; Fanucchi, S. ; Ciucci, G. ; Padoan, G. ; Gasparini, F. ; Guidetti, D. ; De Angelis, D. ; Amabile, G. A. ; Fiermonte Rome, G. ; Roberti, C. ; Foti, A. ; Cainelli, L. ; Chiusole, M. ; Pasqualino, S. ; Intiso, D. ; Giovanni, S. ; Tonizzo, M. ; Basile, A. ; Vito, S. ; Viviani, P. ; Stromillo, M. L. ; Federico, A. ; Liboni, W. ; Pavanelli, E. ; Bergamasco, B. ; Cerrato, P. ; Boghi, A. / Post-stroke depression : Research methodology of a large multicentre observational study (DESTRO). In: Neurological Sciences. 2004 ; Vol. 25, No. 3. pp. 138-144.
@article{b47454ab1cda4df8a865670c98a8f007,
title = "Post-stroke depression: Research methodology of a large multicentre observational study (DESTRO)",
abstract = "The heterogeneity of published data regarding post-stroke depression (PSD) prompted an Italian multicenter observational study (DESTRO), which took place in 2000-2003. The investigation involved 53 Italian neurology centers: of these, 50 treat acute patients and 3 provide rehabilitation care; 21 centres are in Northern Italy, 20 are in Central Italy, and 12 are in Southern Italy. The time schedule was articulated into three phases: registration of 6289 stroke patients; selection of 1817 cases and enrolment of 1074 patients; and follow-up for two years (1064 patients). Mood assessment was performed by evaluating depressive symptoms according to DSM IV and the Beck depression inventory (visual analog mood scale for aphasic patients). Depressed patients were also administered the Montgomery-Asberg depression rating scale. Scores were related to function (Barthel index, modified Rankin scale), cognition (MMSE), quality of life (SF-36), and clinical data. Data analysis will provide information on PSD prevalence, onset and evolution, correlation with ischemic clinical syndrome, impact on activities of daily living, cognitive level and quality of life. The few data available at the present time concern PSD prevalence in the first six months after stroke (33.6{\%}). DESTRO is a longitudinal investigation of a large patient sample and is expected to provide insights into the relationship of PDS with the functional and clinical consequences of stroke.",
keywords = "Depression, Outcome, Risk factor, Stroke",
author = "V. Toso and C. Gandolfo and S. Paolucci and L. Provinciali and R. Torta and N. Grassivaro and G. Lagalla and Manicone, {M. G.} and {Del Gobbo}, M. and S. Paolini and E. Bottacchi and G. Corso and F. Federico and D. Martino and F. Salsa and E. Turinese and M. Gentile and S. Bogo and M. Crisci and T. Sacquegna and V. Santamato and G. Pietrarossa and G. Coppola and G. Trianni and G. Pennisi and R. Bella and S. Ricci and K. Amantini and S. Buzzelli and {Di Francesco}, L. and B. Antonelli and G. Pelliccia and E. Paolino and E. Iezzi and P. Nencini and C. Sarti and W. Neri and G. Galletti and S. Pretta and {Del Sette}, M. and E. Giaccaglini and C. Sconocchini and A. Carolei and C. Capannolo and {De Falco}, {F. A.} and R. Santangelo and R. Musolino and S. Gangemi and R. Vita and {Di Leo}, R. and M. Comola and S. Mammi and Zamperretti, {M. A.} and Delfanti, {C. A.} and S. Sommacal and G. Rudelli and V. Scarano and G. Coppola and Giordana, {M. P.} and R. Sciolla and G. Meneghetti and M. Ottina and A. Ponari and R. Castiglia and D. Mancia and C. Zanferrari and G. Micieli and E. Zambrelli and G. Cardaioli and V. Gallai and R. Badino and T. Tassinari and G. Orlandi and S. Fanucchi and G. Ciucci and G. Padoan and F. Gasparini and D. Guidetti and {De Angelis}, D. and Amabile, {G. A.} and {Fiermonte Rome}, G. and C. Roberti and A. Foti and L. Cainelli and M. Chiusole and S. Pasqualino and D. Intiso and S. Giovanni and M. Tonizzo and A. Basile and S. Vito and P. Viviani and Stromillo, {M. L.} and A. Federico and W. Liboni and E. Pavanelli and B. Bergamasco and P. Cerrato and A. Boghi",
year = "2004",
month = "7",
language = "English",
volume = "25",
pages = "138--144",
journal = "Neurological Sciences",
issn = "1590-1874",
publisher = "Springer-Verlag Italia s.r.l.",
number = "3",

}

TY - JOUR

T1 - Post-stroke depression

T2 - Research methodology of a large multicentre observational study (DESTRO)

AU - Toso, V.

AU - Gandolfo, C.

AU - Paolucci, S.

AU - Provinciali, L.

AU - Torta, R.

AU - Grassivaro, N.

AU - Lagalla, G.

AU - Manicone, M. G.

AU - Del Gobbo, M.

AU - Paolini, S.

AU - Bottacchi, E.

AU - Corso, G.

AU - Federico, F.

AU - Martino, D.

AU - Salsa, F.

AU - Turinese, E.

AU - Gentile, M.

AU - Bogo, S.

AU - Crisci, M.

AU - Sacquegna, T.

AU - Santamato, V.

AU - Pietrarossa, G.

AU - Coppola, G.

AU - Trianni, G.

AU - Pennisi, G.

AU - Bella, R.

AU - Ricci, S.

AU - Amantini, K.

AU - Buzzelli, S.

AU - Di Francesco, L.

AU - Antonelli, B.

AU - Pelliccia, G.

AU - Paolino, E.

AU - Iezzi, E.

AU - Nencini, P.

AU - Sarti, C.

AU - Neri, W.

AU - Galletti, G.

AU - Pretta, S.

AU - Del Sette, M.

AU - Giaccaglini, E.

AU - Sconocchini, C.

AU - Carolei, A.

AU - Capannolo, C.

AU - De Falco, F. A.

AU - Santangelo, R.

AU - Musolino, R.

AU - Gangemi, S.

AU - Vita, R.

AU - Di Leo, R.

AU - Comola, M.

AU - Mammi, S.

AU - Zamperretti, M. A.

AU - Delfanti, C. A.

AU - Sommacal, S.

AU - Rudelli, G.

AU - Scarano, V.

AU - Coppola, G.

AU - Giordana, M. P.

AU - Sciolla, R.

AU - Meneghetti, G.

AU - Ottina, M.

AU - Ponari, A.

AU - Castiglia, R.

AU - Mancia, D.

AU - Zanferrari, C.

AU - Micieli, G.

AU - Zambrelli, E.

AU - Cardaioli, G.

AU - Gallai, V.

AU - Badino, R.

AU - Tassinari, T.

AU - Orlandi, G.

AU - Fanucchi, S.

AU - Ciucci, G.

AU - Padoan, G.

AU - Gasparini, F.

AU - Guidetti, D.

AU - De Angelis, D.

AU - Amabile, G. A.

AU - Fiermonte Rome, G.

AU - Roberti, C.

AU - Foti, A.

AU - Cainelli, L.

AU - Chiusole, M.

AU - Pasqualino, S.

AU - Intiso, D.

AU - Giovanni, S.

AU - Tonizzo, M.

AU - Basile, A.

AU - Vito, S.

AU - Viviani, P.

AU - Stromillo, M. L.

AU - Federico, A.

AU - Liboni, W.

AU - Pavanelli, E.

AU - Bergamasco, B.

AU - Cerrato, P.

AU - Boghi, A.

PY - 2004/7

Y1 - 2004/7

N2 - The heterogeneity of published data regarding post-stroke depression (PSD) prompted an Italian multicenter observational study (DESTRO), which took place in 2000-2003. The investigation involved 53 Italian neurology centers: of these, 50 treat acute patients and 3 provide rehabilitation care; 21 centres are in Northern Italy, 20 are in Central Italy, and 12 are in Southern Italy. The time schedule was articulated into three phases: registration of 6289 stroke patients; selection of 1817 cases and enrolment of 1074 patients; and follow-up for two years (1064 patients). Mood assessment was performed by evaluating depressive symptoms according to DSM IV and the Beck depression inventory (visual analog mood scale for aphasic patients). Depressed patients were also administered the Montgomery-Asberg depression rating scale. Scores were related to function (Barthel index, modified Rankin scale), cognition (MMSE), quality of life (SF-36), and clinical data. Data analysis will provide information on PSD prevalence, onset and evolution, correlation with ischemic clinical syndrome, impact on activities of daily living, cognitive level and quality of life. The few data available at the present time concern PSD prevalence in the first six months after stroke (33.6%). DESTRO is a longitudinal investigation of a large patient sample and is expected to provide insights into the relationship of PDS with the functional and clinical consequences of stroke.

AB - The heterogeneity of published data regarding post-stroke depression (PSD) prompted an Italian multicenter observational study (DESTRO), which took place in 2000-2003. The investigation involved 53 Italian neurology centers: of these, 50 treat acute patients and 3 provide rehabilitation care; 21 centres are in Northern Italy, 20 are in Central Italy, and 12 are in Southern Italy. The time schedule was articulated into three phases: registration of 6289 stroke patients; selection of 1817 cases and enrolment of 1074 patients; and follow-up for two years (1064 patients). Mood assessment was performed by evaluating depressive symptoms according to DSM IV and the Beck depression inventory (visual analog mood scale for aphasic patients). Depressed patients were also administered the Montgomery-Asberg depression rating scale. Scores were related to function (Barthel index, modified Rankin scale), cognition (MMSE), quality of life (SF-36), and clinical data. Data analysis will provide information on PSD prevalence, onset and evolution, correlation with ischemic clinical syndrome, impact on activities of daily living, cognitive level and quality of life. The few data available at the present time concern PSD prevalence in the first six months after stroke (33.6%). DESTRO is a longitudinal investigation of a large patient sample and is expected to provide insights into the relationship of PDS with the functional and clinical consequences of stroke.

KW - Depression

KW - Outcome

KW - Risk factor

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=4344614182&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4344614182&partnerID=8YFLogxK

M3 - Article

VL - 25

SP - 138

EP - 144

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

IS - 3

ER -