Post-therapy surveillance of patients with uterine cancers: Value of integrated FDG PET/CT in the detection of recurrence

Sandro Sironi, Maria Picchio, Claudio Landoni, Stefania Galimberti, Mauro Signorelli, Valentino Bettinardi, Patrizia Perego, Costantino Mangioni, Cristina Messa, Ferruccio Fazio

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The purpose of this study was to prospectively determine the diagnostic accuracy of PET/CT in the detection of recurrence in patients with treated uterine cancers. Methods: Twenty-five women, ranging in age from 37 to 79 years (mean 58.9 years), who underwent primary surgical treatment for either a cervical or an endometrial cancer met the inclusion criterion of the study, which was suspicion of recurrence based on results of routine follow-up procedures. PET/CT was performed after administration of 18F- fluorodeoxyglucose (FDG); two readers interpreted the images in consensus. Histopathological findings or correlation with results of subsequent clinical and imaging follow-up examinations served as the reference standard. Diagnostic accuracy of PET/CT was reported in terms of the proportion of correctly classified patients and lesion sites. Results: Tumour recurrence was found at histopathological analysis or follow-up examinations after PET/CT in 14 (56%) of the 25 patients. Patient-based sensitivity, specificity, positive predictive value, negative predictive value and accuracy of PET/CT for detection of tumour recurrence were 92.9%, 100.0%, 100.0%, 91.7% and 96.0%, respectively. Lesion site-based sensitivity, specificity, positive predictive value, negative predictive value and accuracy of PET/CT were 94.7%, 99.5%, 94.7%, 99.5% and 99.0%, respectively. Conclusion: This preliminary study shows that PET/CT may be an accurate method for the evaluation of recurrence in patients who have been treated for uterine cancers and are undergoing follow-up.

Original languageEnglish
Pages (from-to)472-479
Number of pages8
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume34
Issue number4
DOIs
Publication statusPublished - Apr 2007

Keywords

  • FDG
  • PET
  • PET/CT
  • Recurrence
  • Uterine cancer

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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