Post translational modification of Parkin

Joy Chakraborty, Valentina Basso, Elena Ziviani

Research output: Contribution to journalReview article

Abstract

Mutations in the gene encoding for the E3 ubiquitin ligase Parkin are associated to a rare form of familiar autosomal recessive Parkinsonism. Despite decades of research on the Parkin protein, whose structure has been recently solved, little is known about the specific signalling pathways that lead to Parkin activation. Parkin activity spans from mitochondria quality control to tumor suppression and stress protection; it is thus tempting to hypothesize that the broad impact of Parkin on cellular physiology might be the result of different post translational modifications that can be controlled by balanced opposing events. Sequence alignment of Parkin from different species indicates high homology between domains across Parkin orthologs and identifies highly conserved amino acid residues that, if modified, impinge on Parkin functions. In this review, we summarize findings on post translational modifications that have been shown to affect Parkin activity and stability. Reviewers: This article was reviewed by Prof. Dr. Konstanze F. Winklhofer and by Prof. Thomas Simmen. Both reviewers have been nominated by Professor Luca Pellegrini.

Original languageEnglish
Article number6
JournalBiology Direct
Volume12
Issue number1
DOIs
Publication statusPublished - Feb 21 2017

Keywords

  • Parkin
  • Parkinson's disease
  • Phosphorylation
  • Post translational modifications
  • Ubiquitination

ASJC Scopus subject areas

  • Immunology
  • Ecology, Evolution, Behavior and Systematics
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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  • Cite this

    Chakraborty, J., Basso, V., & Ziviani, E. (2017). Post translational modification of Parkin. Biology Direct, 12(1), [6]. https://doi.org/10.1186/s13062-017-0176-3