TY - JOUR
T1 - Post-transplant consolidation based on combination of lenalidomide and proteasome inhibitors in multiple myeloma
AU - Romano, Alessandra
AU - Santoro, Marco
AU - Conticello, Concetta
AU - Siragusa, Sergio
AU - DI Raimondo, Francesco
AU - Martinelli, Giovanni
AU - Cerchione, Claudio
PY - 2021/3
Y1 - 2021/3
N2 - Multiple myeloma (MM) is a hematological malignancy due to uncontrolled proliferation of neoplastic plasma cells in the bone marrow, associated to chromosomal instability and cytogenetic abnormalities, which could have an impact on prognosis. Response to treatment and survival of newly diagnosed myeloma patients is heterogeneous, with median overall survival ranging from two to more than ten years, due to clinical and biological factors. To warrant long-term control of disease, several strategies have been proposed in the last years, including short-term high-dose of treatment, named as consolidation, before maintenance. This review will discuss the role of consolidation in the current myeloma treatment landscape, and further improvements required to optimize tailored front-line therapy.
AB - Multiple myeloma (MM) is a hematological malignancy due to uncontrolled proliferation of neoplastic plasma cells in the bone marrow, associated to chromosomal instability and cytogenetic abnormalities, which could have an impact on prognosis. Response to treatment and survival of newly diagnosed myeloma patients is heterogeneous, with median overall survival ranging from two to more than ten years, due to clinical and biological factors. To warrant long-term control of disease, several strategies have been proposed in the last years, including short-term high-dose of treatment, named as consolidation, before maintenance. This review will discuss the role of consolidation in the current myeloma treatment landscape, and further improvements required to optimize tailored front-line therapy.
U2 - 10.23736/S0031-0808.20.04141-5
DO - 10.23736/S0031-0808.20.04141-5
M3 - Article
C2 - 32955184
VL - 63
SP - 13
EP - 20
JO - Panminerva Medica
JF - Panminerva Medica
SN - 0031-0808
IS - 1
ER -