Post-transplant diabetes mellitus and HCV seropositive status after renal transplantation: Meta-analysis of clinical studies

Fabrizio Fabrizi, Paul Martin, Vivek Dixit, Suphamai Bunnapradist, Fasiha Kanwal, Gareth Dulai

Research output: Contribution to journalArticle

Abstract

Hepatitis C virus (HCV) infection has a detrimental role on patient and graft survival after renal transplantation (RT). Some studies have also implicated HCV in the development of post-transplant diabetes mellitus (PTDM). We conducted a systematic review of the published medical literature of the relationship between anti-HCV seropositive status and DM after RT. The risk of DM occurrence in anti-HCV-positive and -negative patients after RT was regarded as the most reliable outcome end-point. We used the random effects model of DerSimonian and Laird to generate a summary estimate of the Odds Ratio (OD) of new onset DM in HCV-positive and -negative patients after kidney transplantation. Ten studies involving 2502 unique RT recipients were identified. The incidence of PTDM after RT ranged between 7.9% and 50%. The summary estimate for adjusted OR was 3.97 with a 95% confidence interval (CI) of 1.83-8.61 (p-value for homogeneity

Original languageEnglish
Pages (from-to)2433-2440
Number of pages8
JournalAmerican Journal of Transplantation
Volume5
Issue number10
DOIs
Publication statusPublished - Oct 2005

Keywords

  • Diabetes mellitus
  • Hepatitis C virus (HCV)
  • Meta-analysis
  • Observational studies
  • Renal transplantation (RT)

ASJC Scopus subject areas

  • Immunology

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