Postantibiotic effect and delay of regrowth in strains carrying mutations that save proteins or RNA

Marzia Dolcino, Alberto Zoratti, Eugenio A. Debbia, Gian Carlo Schito, Anna Marchese

Research output: Contribution to journalArticle

Abstract

The postantibiotic effect (PAE) values found for proteinase-defective (Lon-) Escherichia coli and RNase-defective E. coli exposed to antibiotics were reduced (31 to 60% and 35 to 50%, respectively) in comparison with the control (AB1157), and in the recA13 mutant these values were about 0.4 h with all drugs. Nalidixic acid, under anaerobic conditions, induced no PAE (0 to 0.1 h) in AB1157. A delay in regrowth (0.2 to 0.26 h) was noted with dnaA46(Ts), gyrA43(Ts), and gyrB41 (Ts) mutants cultured for 2 h at 43°C. These findings suggest that when proteins and RNA are saved, the cell rapidly resumes the original growth rate.

Original languageEnglish
Pages (from-to)4022-4025
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume46
Issue number12
DOIs
Publication statusPublished - Dec 1 2002

ASJC Scopus subject areas

  • Pharmacology (medical)

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