Posterior fossa malformations and epilepsy

Antonia Parmeggiani, Annio Posar, Maria Cristina Scaduto, Simona Chiodo, Margherita Santucci, Paola Giovanardi Rossi

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The association between posterior fossa malformations and epilepsy is rarely reported in the literature. We describe 54 cases with posterior fossa malformations, according to embryogenesis classification, divided into two groups on the basis of presence or absence of epilepsy. Epilepsy occurred in 22 cases (40.7%) and was not related to the type of posterior fossa malformation or to supratentorial cerebral lesions associated with the malformation. Familial antecedents for epilepsy and/or febrile convulsions influenced the presence of epilepsy in patients with posterior fossa malformations (P <.01). Epilepsy was mainly partial (77.3%); benign partial/generalized epilepsies and febrile convulsions occurred in 27.3% of cases. Seizures disappeared for 2 or more years at the end of follow-up in 36.4% of patients. Good epilepsy prognosis was not related to the age at onset of seizures, familial antecedents for epilepsy and/or febrile convulsions, supratentorial associated lesions, or age of patients at the last observation. Profound mental retardation prevailed in patients with epilepsy (P <.01), as did pathologic electroencephalograms (EEG) (P <.0001), with paroxysmal abnormalities (P <.001) and asymmetry (P <.01). In our 54 cases of posterior fossa malformation, we identified two risk factors for epilepsy: familial antecedents for epilepsy and/or febrile convulsions and the involvement of the cerebellum in the malformation.

Original languageEnglish
Pages (from-to)113-117
Number of pages5
JournalJournal of Child Neurology
Issue number2
Publication statusPublished - Feb 1999

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

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    Parmeggiani, A., Posar, A., Scaduto, M. C., Chiodo, S., Santucci, M., & Rossi, P. G. (1999). Posterior fossa malformations and epilepsy. Journal of Child Neurology, 14(2), 113-117.