Posterior pituitary (PP) evaluation in patients with anterior pituitary defect associated with ectopic PP and septo-optic dysplasia

Andrea Secco, Anna Elsa Maria Allegri, Natascia Di Iorgi, Flavia Napoli, AnnaLisa Calcagno, Enrica Bertelli, Irene Olivieri, Giovanna Pala, Stefano Parodi, Roberto Gastaldi, Andrea Rossi, Mohamad Maghnie

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Controversies exist about posterior pituitary (PP) function in subjects with ectopic PP (EPP) and with cerebral midline defects and/or their co-occurrence. We investigate water and electrolyte disturbances in patients at risk for PP dysfunction. Design: The study was conducted in a single Pediatric Endocrinology Research Unit. Methods: Forty-two subjects with childhood-onset GH deficiency were subdivided into five groups: normal magnetic resonance imaging (n=8, group 1); EPP (n=15, group 2); septo-optic dysplasia (SOD) with normal PP (n=4, group 3); EPP and SOD without (n=7, group 4), and with additional midline brain abnormalities (n=8, group 5). At a mean age of 16.0±1.1 years, they underwent a 120 min i.v. infusion with hypertonic 5% saline and evaluation of plasma osmolality (Posm), arginine vasopressin (AVP), thirst score (in groups 1 and 2), and urinary osmolality were performed. Results: Mean Posm and AVP significantly increased from baseline scores (284.7±4.9 mosm/kg and 0.6±0.2 pmol/l) to 120 min after saline infusion (300.5±8.0 mosm/kg and 10.3±3.3 pmol/l, P

Original languageEnglish
Pages (from-to)411-420
Number of pages10
JournalEuropean Journal of Endocrinology
Volume165
Issue number3
DOIs
Publication statusPublished - Sep 2011

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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