Posterior polymorphous corneal dystrophy concomitant to large colloid drusen

Claudia Del Turco, Luisa Pierro, Giuseppe Querques, Marco Gagliardi, Federico Corvi, Maria Pia Manitto, Francesco M. Bandello

Research output: Contribution to journalArticlepeer-review


Purpose: To describe the previously unreported concomitance of 2 uncommon ocular conditions: posterior polymorphous corneal dystrophy (PPCD) and large colloid drusen (LCD). Methods: A 45-year-old woman underwent a complete ophthalmologic examination with slit-lamp biomicroscopy and blue fundus autofluorescence with spectral-domain optical coherence tomography, as well as complete systemic examination and renal function investigation. Results: On slit-lamp biomicroscopy, a corneal lesion located at Descemet membrane was observed in the right eye. The clinical features of deep posterior stromal-endothelial linear bands with vesicles and irregular opacities of posterior corneal surface were consistent with the diagnosis of PPCD. Fundus biomicroscopy and blue fundus autofluorescence showed LCD. Discussions: We report the unusual coexistence of PPCD and LCD in a young, healthy subject. Posterior polymorphous corneal dystrophy and LCD share morphologic similarities and dysfunctions of collagen architecture in the basement membrane layer, which suggests a possible common pathogenic pathway.

Original languageEnglish
Pages (from-to)177-179
Number of pages3
JournalEuropean Journal of Ophthalmology
Issue number2
Publication statusPublished - Oct 8 2014


  • Early-onset
  • Large colloid drusen
  • Macular dystrophy
  • Optical coherence tomography
  • Posterior polymorphous corneal dystrophy
  • Young

ASJC Scopus subject areas

  • Ophthalmology
  • Medicine(all)


Dive into the research topics of 'Posterior polymorphous corneal dystrophy concomitant to large colloid drusen'. Together they form a unique fingerprint.

Cite this