Posterior urethral valves

Long-term outcome

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Posterior urethral valves represent the most common cause of bladder outlet obstruction in infancy that impairs renal and bladder function. Long-term outcome of patients with previous PUV is evaluated. Patients over 18 years of age, treated from 1982 to 1995 before the age of 3 years were considered. Previous surgery, renal function, bladder activity, urinary incontinence, and fertility/sexual activity were evaluated. Clinical interview, creatinine clearance, uroflowmetry with ultrasound post-void urine residue, and self-administered questionnaire were recorded. Out of 45 identified records, 24 patients (53.3%) accepted to be enrolled (age 18-34 years, mean 23 years). The mean follow-up was 19.5 years (16-30 years). Out of the 21 excluded patients, 20 did not reply to the clinical interview and 1 died at age of 6 years. All the 24 patients had early endoscopic section of PUV; nine also received transient ureterocutaneostomy or vesicostomy. Ureteroneocystostomy was performed in five patients and ureterocystoplasty with unilateral nephrectomy in two. At follow-up chronic renal failure was detected in 13 patients (54.1%) and 9 (37.5%) had arterial hypertension. End-stage renal disease developed in five patients (20.8%): three had successful renal transplantation and two were in dialysis. Lower urinary tract symptoms were present in seven patients (29.1%). No significant fertility deficit and sexual dysfunction were observed in 23 patients, while 1 patient was azoospermic. No paternity was reported so far. Long-term outcome of patients with previously treated PUV is mandatory. Kidney, bladder, and sexual functions should be monitored till adulthood to verify any modified behaviour.

Original languageEnglish
Pages (from-to)1027-1035
Number of pages9
JournalPediatric Surgery International
Volume27
Issue number10
DOIs
Publication statusPublished - Oct 2011

Fingerprint

Urinary Bladder
Kidney
Chronic Kidney Failure
Fertility
Cystostomy
Interviews
Urinary Bladder Neck Obstruction
Paternity
Lower Urinary Tract Symptoms
Urinary Incontinence
Nephrectomy
Sexual Behavior
Kidney Transplantation
Dialysis
Creatinine
Urine
Hypertension
Surveys and Questionnaires

Keywords

  • Adolescent urology
  • ESRD
  • Long-term follow-up
  • Obstructive uropathy
  • Posterior uretral valves

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

Posterior urethral valves : Long-term outcome. / Caione, Paolo; Nappo, Simona Gerocarni.

In: Pediatric Surgery International, Vol. 27, No. 10, 10.2011, p. 1027-1035.

Research output: Contribution to journalArticle

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