Postheparin plasma diamine oxidase values in the follow up of patients with small bowel Crohn's disease

L. D'Agostino, S. Pignata, B. Daniele, M. Visconti, C. Ferraro, G. D'Adamo, G. Tritto, G. Ambrogio, G. Mazzacca

Research output: Contribution to journalArticlepeer-review

Abstract

Measurement of postheparin plasma diamine oxidase (PHD) activity has been proposed to assess mucosal integrity in several diseases of the small intestine. In Crohn's disease, PHD values identify a group of patients with predominantly small bowel mucosal damage. To determine the role of mucosal involvement in the progression of small bowel Crohn's disease and whether different PHD values can predict different outcomes the changes in PHD values in 41 patients with small bowel Crohn's disease admitted consecutively to our department were investigated. The test was performed during periods of active disease and after either medical or surgical treatment had resulted in improvement. PHD values were significantly lower than in normal subjects (normal range 3.7-7.7 U/ml). In 35 patients with active disease (Crohn's disease activity index (CDAI) >150) two groups were identified by choosing a cut off value of 2 U/ml: 93% of the 15 patients with PHD values lower than 2 U/mi (mean (SD) 1.36 (0.46) U/ml) relapsed at least once in the following year, while only the 20% of the 20 whose values were higher than 2 U/ml (mean (SD) 3.69 (1.50)) relapsed in the same period. The data were statistically significant (Yates's corrected χ2=15.63; p

Original languageEnglish
Pages (from-to)932-935
Number of pages4
JournalGut
Volume32
Issue number8
DOIs
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Gastroenterology

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