Postmastectomy radiotherapy and concomitant adjuvant chemotherapy versus adjuvant chemotherapy alone in premenopausal breast cancer patients with positive axillary nodes

E. Micheletti, B. La Face, A. Huscher, G. Catalano, E. Ambrosi, G. Marini, E. Simoncini

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: To evaluate the efficacy of postmastectomy radiotherapy (RT) combined with adjuvant chemotherapy compared to adjuvant chemotherapy alone as regards overall survival (OS), overall disease-free survival (ODFS), local disease-free survival (LDFS) and distant disease-free survival (DDFS). Methods: We reviewed retrospectively two non-randomized groups of premenopausal high-risk breast cancer patients treated from 1985 to 1990 in the following institutions: Department of Radiation Oncology of Brescia University, 'Istituto del Radio O. Alberti' (IRA), and Department of Oncology of Brescia Hospital 'Beretta Foundation' (BF). A total of 163 patients was found to satisfy the criteria of the current analysis: 81 patients received adjuvant chemotherapy alone [6 cycles CMF(1-8)] at BF and 82 patients received postoperative radiotherapy and chemotherapy [8 cycles CMF(1-21)] at IRA. A modified CMF schedule was chosen at IRA to avoid the feared increase in toxicity due to the association with RT. Primary surgical treatment was modified radical mastectomy with axillary node dissection in both cases. Results: A statistically significant improvement in OS was found in systemic adjuvant therapy patients compared to those also given RT (77.6% vs 59%; P = 0.0025). No statistically significant improvement in ODFS was found in the CMF(1-8) arm compared to the RT and CMF(1-21) stm: 51.6% vs 43.6%; P = 0.46. A statistically significant improvement in LDFS at 5 years was found in irradiated patients (89.3% vs 76.2%; P

Original languageEnglish
Pages (from-to)652-658
Number of pages7
JournalTumori
Volume84
Issue number6
Publication statusPublished - 1998

Keywords

  • Breast cancer
  • CMF
  • High-risk breast cancer
  • Postmastectomy radiotherapy

ASJC Scopus subject areas

  • Cancer Research

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