Postmenarchal Down's syndrome: A theoretical model of growth hormone action on ovarian function

R. M. Cento, C. Proto, M. Guido, A. Lanzone

Research output: Contribution to journalArticlepeer-review

Abstract

Much evidence indicates that blunted ovarian sensitivity to follicle-stimulating hormone (FSH) and lower growth hormone (GH) plasma concentrations, as often occur in women with Down's syndrome (DS), may contribute to the gonadal disfunction frequently present in such subjects. In this review, we analyze the more recent advances in this field, and then discuss from a clinical point of view the potential role of GH on ovarian function, since DS patients may also constitute a theoretical model for investigating this particular aspect of reproductive physiology.

Original languageEnglish
Pages (from-to)81-88
Number of pages8
JournalGynecological Endocrinology
Volume15
Issue number1
Publication statusPublished - 2001

Keywords

  • Down's syndrome
  • Growth hormone
  • Menarche
  • Ovarian function

ASJC Scopus subject areas

  • Endocrinology
  • Obstetrics and Gynaecology

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