Postnatal development of the glutamate vesicular transporter VGLUT1 in rat cerebral cortex

Andrea Minelli; Robert H. Edwards; Tullio Manzoni; Fiorenzo Conti

doi:10.1016/S0165-3806(02)00617-X

Postnatal development of the glutamate vesicular transporter VGLUT1 in rat cerebral cortex

Andrea Minelli, Robert H. Edwards, Tullio Manzoni, Fiorenzo Conti

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article › peer-review

Abstract

The expression of the vesicular glutamate transporter VGLUT1 in the rat neocortex was studied during postnatal development using immunocytochemistry and Western blotting. At all ages, VGLUT immunoreactivity is localized to puncta that coexpress the presynaptic marker synaptophysin. VGLUT1 immunoreactivity is faint at birth, increases in the subplate during the first postnatal week, invades the supragranular layers in the second week and reaches the adult pattern at P20-P30. Its spatial and temporal maturation patterns suggest that VGLUT1 may be the vesicular transporter in developing corticocortical connections.

Original language	English
Pages (from-to)	309-314
Number of pages	6
Journal	Developmental Brain Research
Volume	140
Issue number	2
DOIs	https://doi.org/10.1016/S0165-3806(02)00617-X
Publication status	Published - Feb 16 2003

Keywords

Associative connection
Callosal connection
Development
Glutamate
Glutamate transporter
Neocortex
Vesicle

ASJC Scopus subject areas

Developmental Biology
Developmental Neuroscience

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10.1016/S0165-3806(02)00617-X

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abstract = "The expression of the vesicular glutamate transporter VGLUT1 in the rat neocortex was studied during postnatal development using immunocytochemistry and Western blotting. At all ages, VGLUT immunoreactivity is localized to puncta that coexpress the presynaptic marker synaptophysin. VGLUT1 immunoreactivity is faint at birth, increases in the subplate during the first postnatal week, invades the supragranular layers in the second week and reaches the adult pattern at P20-P30. Its spatial and temporal maturation patterns suggest that VGLUT1 may be the vesicular transporter in developing corticocortical connections.",

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T1 - Postnatal development of the glutamate vesicular transporter VGLUT1 in rat cerebral cortex

AU - Minelli, Andrea

AU - Edwards, Robert H.

AU - Manzoni, Tullio

AU - Conti, Fiorenzo

PY - 2003/2/16

Y1 - 2003/2/16

N2 - The expression of the vesicular glutamate transporter VGLUT1 in the rat neocortex was studied during postnatal development using immunocytochemistry and Western blotting. At all ages, VGLUT immunoreactivity is localized to puncta that coexpress the presynaptic marker synaptophysin. VGLUT1 immunoreactivity is faint at birth, increases in the subplate during the first postnatal week, invades the supragranular layers in the second week and reaches the adult pattern at P20-P30. Its spatial and temporal maturation patterns suggest that VGLUT1 may be the vesicular transporter in developing corticocortical connections.

AB - The expression of the vesicular glutamate transporter VGLUT1 in the rat neocortex was studied during postnatal development using immunocytochemistry and Western blotting. At all ages, VGLUT immunoreactivity is localized to puncta that coexpress the presynaptic marker synaptophysin. VGLUT1 immunoreactivity is faint at birth, increases in the subplate during the first postnatal week, invades the supragranular layers in the second week and reaches the adult pattern at P20-P30. Its spatial and temporal maturation patterns suggest that VGLUT1 may be the vesicular transporter in developing corticocortical connections.

KW - Associative connection

KW - Callosal connection

KW - Development

KW - Glutamate

KW - Glutamate transporter

KW - Neocortex

KW - Vesicle

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Postnatal development of the glutamate vesicular transporter VGLUT1 in rat cerebral cortex

Abstract

Keywords

ASJC Scopus subject areas

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