Postnatal variations of growth hormone bioactivity and of growth hormone-dependent factors

Mauro Bozzola, Katia Tettoni, Franco Locatelli, Giorgio Radetti, Cesare Belloni, Michele Autelli, Marco Zecca, Roberta Valentini, Francesca Severi, Luciano Tatò

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate whether the low insulinlike growth factor I (IGF- I) levels that are observed in the neonate depend on the biological inactivity of the molecular forms of growth hormone (GH) or on the immaturity of the hepatic GH receptors during the early postnatal period. Materials and Methods: Serum samples were collected from 60 normal full-term neonates on day 5 and at 1 and 4 months of age to evaluate the GH concentrations by using both an immunofluorometric assay and Nb2 cell bioassay, as well as the GH- binding protein, IGF-1, and IGF-binding protein 3 values by radioimmunoassay. Results: Five-day-old neonates showed significantly higher (P

Original languageEnglish
Pages (from-to)1068-1071
Number of pages4
JournalArchives of Pediatrics and Adolescent Medicine
Volume150
Issue number10
Publication statusPublished - Oct 1996

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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