Postoperative 5-FU based Radiochemotherapy in Rectal Cancer: Retrospective Long Term Results and Prognostic Factors of a Pooled Analysis on 1,338 Patients

Domenico Genovesi, Robert J. Myerson, Giampiero Ausili Cèfaro, Annamaria Vinciguerra, Antonietta Augurio, Marianna Trignani, Monica Di Tommaso, Marianna Nuzzo, Marco Lupattelli, Cynthia Aristei, Rita Bellavita, Luciano Scandolaro, Dorian Cosentino, Giuseppe Pani, Luigi Ziccarelli, Maria A. Gambacorta, Maria C. Barba, Ernesto Maranzano, Fabio Trippa, Piera SciaceroRita Niespolo, Cristina Leonardi, Tiziana Iannone, Maria Elena Rosetto, Vincenzo Fusco, Piero Sanpaolo, Antonella Melano, Francesca Valvo, Carlo Capirci, Antonino De Paoli, Marta Di Nicola, Giovanna Mantello, Vincenzo Valentini

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To evaluate survival outcomes of patients in pStage II-III rectal cancer treated with adjuvant 5-fluorouracil-based radiochemotherapy and toretrospectively analyzethe impact of prognostic variables on local control, metastasis-free survival and cause-specific survival. Patients and Methods: A total of 1,338 patients, treated between 1985-2005 for locally advanced rectal cancer, who underwent surgery and postoperative 5-fluorouracil-based chemoradiation, were selected. Results: The actuarial 5- and 10-year outcomes were: local control 87.0%-84.1%, disease-free survival 61.6%-52.1%, metastasis-free survival 72.0%-67.2%, cause-specific survival 70.4%-57.5%, and overall survival 63.8%-53.4%. Better outcomes were observed in patients with IIA, IIIA stage. Multivariate analyses showed that variables significantly affecting metastasis-free survival were pT4 and pN2, while for cancer-specific survival those variables were age >65 years, pT4, pN1, pN2, distal tumors and number of lymph nodes removed ≤12. Conclusion: This study confirmed that among stage II-III rectal cancer patients there are subgroups of patients with different clinical outcomes.

Original languageEnglish
Pages (from-to)4557-4566
Number of pages10
JournalAnticancer Research
Volume33
Issue number10
Publication statusPublished - Oct 2013

Keywords

  • Adjuvant therapy
  • Prognostic factors
  • Rectal cancer
  • Staging

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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