TY - JOUR
T1 - Postoperative enteral versus parenteral nutrition in malnourished patients with gastrointestinal cancer
T2 - A randomised multicentre trial
AU - Bozzetti, F.
AU - Braga, M.
AU - Gianotti, L.
AU - Gavazzi, C.
AU - Mariani, L.
PY - 2001/11/3
Y1 - 2001/11/3
N2 - Background: Although current opinion favours the use of enteral over parenteral nutrition, the clinical benefits of early postoperative nutrition in patients undergoing elective surgery have never been clearly shown. We aimed to test the hypothesis that postoperative enteral nutrition is better (fewer postoperative complications) than parenteral nutrition containing similar energy and nitrogen amounts (112 kJ kg -1day -1 and 1.4 g aminoacid kg -1day -1). Methods: We did a randomised multicentre clinical trial in patients with gastrointestinal cancer who were malnourished and candidates for major elective surgery. 159 patients were assigned to enteral nutrition and 158 to parenteral nutrition. The primary endpoint was the occurrence of postoperative complications, and secondary endpoints were length of postoperative hospital stay, adverse effects, and treatment crossover. Analysis was by intention to treat. Findings: Postoperative complications occurred in 54 (34%) patients fed enterally versus 78 (49%) fed parenterally (relative risk 0.69, 95% CI 0.53-0.90, p=0.005). Length of postoperative stay was 13.4 days and 15.0 days in the enteral nutrition and parenteral nutrition groups, respectively (p=0.009). Adverse effects occurred in 56 (35%) patients fed enterally versus 22 (14%) patients fed parenterally (2.50, 1.61-3.86, p
AB - Background: Although current opinion favours the use of enteral over parenteral nutrition, the clinical benefits of early postoperative nutrition in patients undergoing elective surgery have never been clearly shown. We aimed to test the hypothesis that postoperative enteral nutrition is better (fewer postoperative complications) than parenteral nutrition containing similar energy and nitrogen amounts (112 kJ kg -1day -1 and 1.4 g aminoacid kg -1day -1). Methods: We did a randomised multicentre clinical trial in patients with gastrointestinal cancer who were malnourished and candidates for major elective surgery. 159 patients were assigned to enteral nutrition and 158 to parenteral nutrition. The primary endpoint was the occurrence of postoperative complications, and secondary endpoints were length of postoperative hospital stay, adverse effects, and treatment crossover. Analysis was by intention to treat. Findings: Postoperative complications occurred in 54 (34%) patients fed enterally versus 78 (49%) fed parenterally (relative risk 0.69, 95% CI 0.53-0.90, p=0.005). Length of postoperative stay was 13.4 days and 15.0 days in the enteral nutrition and parenteral nutrition groups, respectively (p=0.009). Adverse effects occurred in 56 (35%) patients fed enterally versus 22 (14%) patients fed parenterally (2.50, 1.61-3.86, p
UR - http://www.scopus.com/inward/record.url?scp=0035802738&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035802738&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(01)06578-3
DO - 10.1016/S0140-6736(01)06578-3
M3 - Article
C2 - 11705560
AN - SCOPUS:0035802738
VL - 358
SP - 1487
EP - 1492
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 9292
ER -