Postoperative management of patients with total exocrine pancreatic insufficiency

M. Braga, A. Zerbi, S. Dal Cin, R. De Franchis, A. Malesci, V. Di Carlo

Research output: Contribution to journalArticlepeer-review


The occurrence of maldigestion and malnutrition was studied in 14 patients who had undergone pancreaticoduodenectomy and occlusion of the Wirsung duct with Neoprene(®). Before discharge patients were put on a 70 g/day dietary fat intake. Mean faecal fat excretion was 32.9 g/day without enzyme replacement and fell to 14.2 g/day with pancrelipase supplementation. At discharge all patients were underweight (88 per cent of the usual mean body-weight) and nine patients showed alteration in laboratory nutritional parameters. At the time of discharge a low-fat diet (50 g/day) was prescribed. Six months after surgery, mean faecal fat excretion decreased further to 8.3 g/day (P <0.01) and all patients but one gained weight, reaching 93 per cent of the usual mean body-weight with normalized nutritional parameters. Our data show that the combination of enzyme replacement therapy and low-fat diet allows good correction of steatorrhoea and a significant improvement in nutritional status.

Original languageEnglish
Pages (from-to)669-672
Number of pages4
JournalBritish Journal of Surgery
Issue number6
Publication statusPublished - 1990


  • nutritional status
  • pancreatic enzymes
  • pancreaticoduodenectomy
  • steatorrhoea

ASJC Scopus subject areas

  • Surgery


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