NUTRIZIONE POSTOPERATORIA 'PROTEIN SPARING'

STUDIO PROSPETTICO RANDOMIZZATO MULTICENTRICO SU 678 PAZIENTI

Translated title of the contribution: Postoperative protein sparing therapy: A prospective randomized multicenter study on 678 patients

G. B. Doglietto, L. Gallitelli, R. Bellantone, F. Pacelli, M. Malerba, A. Sgadarf, F. Crucitti, G. Giorgio, O. Paolo, S. Giuseppe, C. Raffaella, L. Agostino, M. Anna, M. Domenico, L. Vincenzo, F. Margiotta, R. Antonio, R. C. Alberto, G. Giuseppe

Research output: Contribution to journalArticle

Abstract

Objective: The metabolic effect of postoperative protein sparing therapy (PST) has been demonstrated by several studies, but the clinical utility of this treatment has not been investigated by large prospective trials. Design: A prospective multicenter randomized trial was designed to evaluate the clinical efficacy of postoperative PST. Patients and Methods: Six hundred and seventyeight patients undergoing major elective abdominal surgery were randomly assigned to receive either protein-sparing therapy after surgery (PST group) or conventional therapy (control group). The patients were monitored for major postoperative complications and mortality. Results: The rate of major postoperative complications were similar in both groups (PST group, 19.5 percent; control group 20.9 percent; p = 0.66), as were the overall postoperative mortality rates (4.7 percent and 3.5 percent, respectively; p = 0.43). There were no differences between PST and control group considering both major infectious and non infectious complications; the rates were 7.7 vs 5 percent (p = 0.15; relative risk 1.02; 95 percent confidence interval 0.98 to 1.07) and 15.1 vs 17.4 percent (p = 0.42; relative risk 0.97; 95 percent interval 0.91 to 1.04) respectively. Also when mildly malnurished patients (n. 147) were considered separately the rates of major postoperative complications resulted comparable in PST group and control patients: 29.9 vs 22.5 percent respectively (p = 0.31). Conclusions: The present study indicates that routine protein therapy for normonurished or mildly malnurished patients undergoing major abdominal surgery is not clinically justified.

Original languageItalian
Pages (from-to)175-182
Number of pages8
JournalRivista Italiana di Nutrizione Parenterale ed Enterale
Volume13
Issue number3
Publication statusPublished - 1995

Fingerprint

Multicenter Studies
therapeutics
Proteins
postoperative complications
proteins
Group Psychotherapy
Control Groups
Therapeutics
surgery
relative risk
Mortality
confidence interval
clinical trials
Confidence Intervals

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Anatomy
  • Nutrition and Dietetics
  • Food Science

Cite this

Doglietto, G. B., Gallitelli, L., Bellantone, R., Pacelli, F., Malerba, M., Sgadarf, A., ... Giuseppe, G. (1995). NUTRIZIONE POSTOPERATORIA 'PROTEIN SPARING': STUDIO PROSPETTICO RANDOMIZZATO MULTICENTRICO SU 678 PAZIENTI. Rivista Italiana di Nutrizione Parenterale ed Enterale, 13(3), 175-182.

NUTRIZIONE POSTOPERATORIA 'PROTEIN SPARING' : STUDIO PROSPETTICO RANDOMIZZATO MULTICENTRICO SU 678 PAZIENTI. / Doglietto, G. B.; Gallitelli, L.; Bellantone, R.; Pacelli, F.; Malerba, M.; Sgadarf, A.; Crucitti, F.; Giorgio, G.; Paolo, O.; Giuseppe, S.; Raffaella, C.; Agostino, L.; Anna, M.; Domenico, M.; Vincenzo, L.; Margiotta, F.; Antonio, R.; Alberto, R. C.; Giuseppe, G.

In: Rivista Italiana di Nutrizione Parenterale ed Enterale, Vol. 13, No. 3, 1995, p. 175-182.

Research output: Contribution to journalArticle

Doglietto, GB, Gallitelli, L, Bellantone, R, Pacelli, F, Malerba, M, Sgadarf, A, Crucitti, F, Giorgio, G, Paolo, O, Giuseppe, S, Raffaella, C, Agostino, L, Anna, M, Domenico, M, Vincenzo, L, Margiotta, F, Antonio, R, Alberto, RC & Giuseppe, G 1995, 'NUTRIZIONE POSTOPERATORIA 'PROTEIN SPARING': STUDIO PROSPETTICO RANDOMIZZATO MULTICENTRICO SU 678 PAZIENTI', Rivista Italiana di Nutrizione Parenterale ed Enterale, vol. 13, no. 3, pp. 175-182.
Doglietto, G. B. ; Gallitelli, L. ; Bellantone, R. ; Pacelli, F. ; Malerba, M. ; Sgadarf, A. ; Crucitti, F. ; Giorgio, G. ; Paolo, O. ; Giuseppe, S. ; Raffaella, C. ; Agostino, L. ; Anna, M. ; Domenico, M. ; Vincenzo, L. ; Margiotta, F. ; Antonio, R. ; Alberto, R. C. ; Giuseppe, G. / NUTRIZIONE POSTOPERATORIA 'PROTEIN SPARING' : STUDIO PROSPETTICO RANDOMIZZATO MULTICENTRICO SU 678 PAZIENTI. In: Rivista Italiana di Nutrizione Parenterale ed Enterale. 1995 ; Vol. 13, No. 3. pp. 175-182.
@article{15d937839ca149e4b3088ac380f04ae7,
title = "NUTRIZIONE POSTOPERATORIA 'PROTEIN SPARING': STUDIO PROSPETTICO RANDOMIZZATO MULTICENTRICO SU 678 PAZIENTI",
abstract = "Objective: The metabolic effect of postoperative protein sparing therapy (PST) has been demonstrated by several studies, but the clinical utility of this treatment has not been investigated by large prospective trials. Design: A prospective multicenter randomized trial was designed to evaluate the clinical efficacy of postoperative PST. Patients and Methods: Six hundred and seventyeight patients undergoing major elective abdominal surgery were randomly assigned to receive either protein-sparing therapy after surgery (PST group) or conventional therapy (control group). The patients were monitored for major postoperative complications and mortality. Results: The rate of major postoperative complications were similar in both groups (PST group, 19.5 percent; control group 20.9 percent; p = 0.66), as were the overall postoperative mortality rates (4.7 percent and 3.5 percent, respectively; p = 0.43). There were no differences between PST and control group considering both major infectious and non infectious complications; the rates were 7.7 vs 5 percent (p = 0.15; relative risk 1.02; 95 percent confidence interval 0.98 to 1.07) and 15.1 vs 17.4 percent (p = 0.42; relative risk 0.97; 95 percent interval 0.91 to 1.04) respectively. Also when mildly malnurished patients (n. 147) were considered separately the rates of major postoperative complications resulted comparable in PST group and control patients: 29.9 vs 22.5 percent respectively (p = 0.31). Conclusions: The present study indicates that routine protein therapy for normonurished or mildly malnurished patients undergoing major abdominal surgery is not clinically justified.",
keywords = "Abdominal surgery, Postoperative complications, Prospective randomized study, Protein sparing therapy",
author = "Doglietto, {G. B.} and L. Gallitelli and R. Bellantone and F. Pacelli and M. Malerba and A. Sgadarf and F. Crucitti and G. Giorgio and O. Paolo and S. Giuseppe and C. Raffaella and L. Agostino and M. Anna and M. Domenico and L. Vincenzo and F. Margiotta and R. Antonio and Alberto, {R. C.} and G. Giuseppe",
year = "1995",
language = "Italian",
volume = "13",
pages = "175--182",
journal = "Rivista Italiana di Nutrizione Parenterale ed Enterale",
issn = "0393-5582",
publisher = "Wichtig Publishing",
number = "3",

}

TY - JOUR

T1 - NUTRIZIONE POSTOPERATORIA 'PROTEIN SPARING'

T2 - STUDIO PROSPETTICO RANDOMIZZATO MULTICENTRICO SU 678 PAZIENTI

AU - Doglietto, G. B.

AU - Gallitelli, L.

AU - Bellantone, R.

AU - Pacelli, F.

AU - Malerba, M.

AU - Sgadarf, A.

AU - Crucitti, F.

AU - Giorgio, G.

AU - Paolo, O.

AU - Giuseppe, S.

AU - Raffaella, C.

AU - Agostino, L.

AU - Anna, M.

AU - Domenico, M.

AU - Vincenzo, L.

AU - Margiotta, F.

AU - Antonio, R.

AU - Alberto, R. C.

AU - Giuseppe, G.

PY - 1995

Y1 - 1995

N2 - Objective: The metabolic effect of postoperative protein sparing therapy (PST) has been demonstrated by several studies, but the clinical utility of this treatment has not been investigated by large prospective trials. Design: A prospective multicenter randomized trial was designed to evaluate the clinical efficacy of postoperative PST. Patients and Methods: Six hundred and seventyeight patients undergoing major elective abdominal surgery were randomly assigned to receive either protein-sparing therapy after surgery (PST group) or conventional therapy (control group). The patients were monitored for major postoperative complications and mortality. Results: The rate of major postoperative complications were similar in both groups (PST group, 19.5 percent; control group 20.9 percent; p = 0.66), as were the overall postoperative mortality rates (4.7 percent and 3.5 percent, respectively; p = 0.43). There were no differences between PST and control group considering both major infectious and non infectious complications; the rates were 7.7 vs 5 percent (p = 0.15; relative risk 1.02; 95 percent confidence interval 0.98 to 1.07) and 15.1 vs 17.4 percent (p = 0.42; relative risk 0.97; 95 percent interval 0.91 to 1.04) respectively. Also when mildly malnurished patients (n. 147) were considered separately the rates of major postoperative complications resulted comparable in PST group and control patients: 29.9 vs 22.5 percent respectively (p = 0.31). Conclusions: The present study indicates that routine protein therapy for normonurished or mildly malnurished patients undergoing major abdominal surgery is not clinically justified.

AB - Objective: The metabolic effect of postoperative protein sparing therapy (PST) has been demonstrated by several studies, but the clinical utility of this treatment has not been investigated by large prospective trials. Design: A prospective multicenter randomized trial was designed to evaluate the clinical efficacy of postoperative PST. Patients and Methods: Six hundred and seventyeight patients undergoing major elective abdominal surgery were randomly assigned to receive either protein-sparing therapy after surgery (PST group) or conventional therapy (control group). The patients were monitored for major postoperative complications and mortality. Results: The rate of major postoperative complications were similar in both groups (PST group, 19.5 percent; control group 20.9 percent; p = 0.66), as were the overall postoperative mortality rates (4.7 percent and 3.5 percent, respectively; p = 0.43). There were no differences between PST and control group considering both major infectious and non infectious complications; the rates were 7.7 vs 5 percent (p = 0.15; relative risk 1.02; 95 percent confidence interval 0.98 to 1.07) and 15.1 vs 17.4 percent (p = 0.42; relative risk 0.97; 95 percent interval 0.91 to 1.04) respectively. Also when mildly malnurished patients (n. 147) were considered separately the rates of major postoperative complications resulted comparable in PST group and control patients: 29.9 vs 22.5 percent respectively (p = 0.31). Conclusions: The present study indicates that routine protein therapy for normonurished or mildly malnurished patients undergoing major abdominal surgery is not clinically justified.

KW - Abdominal surgery

KW - Postoperative complications

KW - Prospective randomized study

KW - Protein sparing therapy

UR - http://www.scopus.com/inward/record.url?scp=9044249319&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=9044249319&partnerID=8YFLogxK

M3 - Articolo

VL - 13

SP - 175

EP - 182

JO - Rivista Italiana di Nutrizione Parenterale ed Enterale

JF - Rivista Italiana di Nutrizione Parenterale ed Enterale

SN - 0393-5582

IS - 3

ER -