Postoperative radiotherapy in the management of adult soft tissue sarcoma of the extremities: Results with two different total dose, fractionation, and overall treatment time schedules

Cécile Le Péchoux, Marie Cécile Le Deley, Suzette Delaloge, Eric Lartigau, Christine Levy-Piedbois, Sylvie Bonvalot, Axel Le Cesne, Gilles Missenard, Philippe Terrier, Daniel Vanel, Jean Genin, Françoise Fontaine

Research output: Contribution to journalArticle

Abstract

Purpose: This retrospective study was performed to evaluate two postoperative radiotherapy schedules in terms of dose, fractionation, and overall treatment time in soft tissue sarcoma (STS) of the extremities. Methods and Materials: Between January 1984 and December 1993, 62 patients with newly diagnosed localized STS of the extremities were treated with maximal conservative surgery and postoperative radiotherapy (RT). Forty-five patients received 50 Gy with conventional fractionation plus a boost dose (5 to 20 Gy). Seventeen patients had hyperfractionated accelerated radiotherapy (HFART) up to a dose of 45 Gy in 3 weeks. Results: With a median follow-up of 72 months, the 5-year local failure rate was 25%, the 5-year disease-free and overall survival rates were respectively 42% and 62%. The 3-year local relapse, disease-free, and overall survival rates were respectively 16%, 44%, and 70% in the conventional radiotherapy group, and 36%, 47%, and 82% in the HFART group (NS). No factor significantly influenced local control with a trend, however, in favor of conventional RT (p = 0.10). Conclusion: HFART at the dose of 45 Gy does not seem to be superior to the standard RT schedule, neither in terms of local control, survival, nor in terms of long-term side effects. However this dose could be considered too low as well as the power of comparison between the two groups to draw definitive conclusions.

Original languageEnglish
Pages (from-to)879-886
Number of pages8
JournalInternational Journal of Radiation Oncology Biology Physics
Volume44
Issue number4
DOIs
Publication statusPublished - Jul 1 1999

Keywords

  • Combined modality treatment
  • Hyperfractionated accelerated radiotherapy
  • Radiotherapy
  • Soft tissue sarcoma
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

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    Le Péchoux, C., Le Deley, M. C., Delaloge, S., Lartigau, E., Levy-Piedbois, C., Bonvalot, S., Le Cesne, A., Missenard, G., Terrier, P., Vanel, D., Genin, J., & Fontaine, F. (1999). Postoperative radiotherapy in the management of adult soft tissue sarcoma of the extremities: Results with two different total dose, fractionation, and overall treatment time schedules. International Journal of Radiation Oncology Biology Physics, 44(4), 879-886. https://doi.org/10.1016/S0360-3016(99)00077-2