Postoperative radiotherapy (PORT) for early oral cavity cancer (pT1-2,N0-1): A review

Research output: Contribution to journalReview article

Abstract

Early stage (T1-2, N0-1) oral squamous cell carcinoma (OSCC) has a generally favorable prognostic outcome. However, locoregional recurrences can occur in up to 30–35% of patients, and 20% will eventually die of disease. National and international treatment guidelines do not recommend the use of postoperative radiotherapy (PORT) in a setting of early OSCC, and highlight surgery alone as the standard single modality treatment. Notwithstanding, the negative prognostic impact of some adverse pathological features, such as perineural and lymphovascular invasion, poor differentiation, depth of invasion >4 mm, and presence of nodal metastasis, is well known. The advantages of PORT in such scenarios are still debated. The aim of this study was to review the more recent literature to provide evidence on the benefits of PORT in the context of early stage OSCC.

Original languageEnglish
Pages (from-to)67-75
Number of pages9
JournalCritical Reviews in Oncology/Hematology
Volume143
DOIs
Publication statusPublished - Nov 2019

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Mouth Neoplasms
Mouth
Squamous Cell Carcinoma
Radiotherapy
Oral Stage
Guidelines
Neoplasm Metastasis
Recurrence
Therapeutics

Keywords

  • Adverse pathological feature
  • Early stage oral cavity cancer
  • Postoperative radiotherapy

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

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title = "Postoperative radiotherapy (PORT) for early oral cavity cancer (pT1-2,N0-1): A review",
abstract = "Early stage (T1-2, N0-1) oral squamous cell carcinoma (OSCC) has a generally favorable prognostic outcome. However, locoregional recurrences can occur in up to 30–35{\%} of patients, and 20{\%} will eventually die of disease. National and international treatment guidelines do not recommend the use of postoperative radiotherapy (PORT) in a setting of early OSCC, and highlight surgery alone as the standard single modality treatment. Notwithstanding, the negative prognostic impact of some adverse pathological features, such as perineural and lymphovascular invasion, poor differentiation, depth of invasion >4 mm, and presence of nodal metastasis, is well known. The advantages of PORT in such scenarios are still debated. The aim of this study was to review the more recent literature to provide evidence on the benefits of PORT in the context of early stage OSCC.",
keywords = "Adverse pathological feature, Early stage oral cavity cancer, Postoperative radiotherapy",
author = "Eliana Ivaldi and {Di Mario}, Dalila and Alberto Paderno and Cesare Piazza and Paolo Bossi and Iacovelli, {Nicola Alessandro} and Fabiola Incandela and Laura Locati and Carlo Fallai and Ester Orlandi",
year = "2019",
month = "11",
doi = "10.1016/j.critrevonc.2019.08.003",
language = "English",
volume = "143",
pages = "67--75",
journal = "Critical Reviews in Oncology/Hematology",
issn = "1040-8428",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Postoperative radiotherapy (PORT) for early oral cavity cancer (pT1-2,N0-1)

T2 - A review

AU - Ivaldi, Eliana

AU - Di Mario, Dalila

AU - Paderno, Alberto

AU - Piazza, Cesare

AU - Bossi, Paolo

AU - Iacovelli, Nicola Alessandro

AU - Incandela, Fabiola

AU - Locati, Laura

AU - Fallai, Carlo

AU - Orlandi, Ester

PY - 2019/11

Y1 - 2019/11

N2 - Early stage (T1-2, N0-1) oral squamous cell carcinoma (OSCC) has a generally favorable prognostic outcome. However, locoregional recurrences can occur in up to 30–35% of patients, and 20% will eventually die of disease. National and international treatment guidelines do not recommend the use of postoperative radiotherapy (PORT) in a setting of early OSCC, and highlight surgery alone as the standard single modality treatment. Notwithstanding, the negative prognostic impact of some adverse pathological features, such as perineural and lymphovascular invasion, poor differentiation, depth of invasion >4 mm, and presence of nodal metastasis, is well known. The advantages of PORT in such scenarios are still debated. The aim of this study was to review the more recent literature to provide evidence on the benefits of PORT in the context of early stage OSCC.

AB - Early stage (T1-2, N0-1) oral squamous cell carcinoma (OSCC) has a generally favorable prognostic outcome. However, locoregional recurrences can occur in up to 30–35% of patients, and 20% will eventually die of disease. National and international treatment guidelines do not recommend the use of postoperative radiotherapy (PORT) in a setting of early OSCC, and highlight surgery alone as the standard single modality treatment. Notwithstanding, the negative prognostic impact of some adverse pathological features, such as perineural and lymphovascular invasion, poor differentiation, depth of invasion >4 mm, and presence of nodal metastasis, is well known. The advantages of PORT in such scenarios are still debated. The aim of this study was to review the more recent literature to provide evidence on the benefits of PORT in the context of early stage OSCC.

KW - Adverse pathological feature

KW - Early stage oral cavity cancer

KW - Postoperative radiotherapy

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DO - 10.1016/j.critrevonc.2019.08.003

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EP - 75

JO - Critical Reviews in Oncology/Hematology

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