Postoperative radiotherapy with volumetric modulated arc therapy of lacrimal gland carcinoma: Two case reports and literature review

Ester Orlandi, Silvia Takanen, Tommaso Giandini, Eva Iannacone, Walter Fontanella, Laura Locati, Mauro Carrara, Paolo Bossi, Cristiana Bergamini, Roberta Granata, Vincenzo Tombolini, Tullio Ibba, Lisa Licitra, Emanuele Pignoli, Carlo Fallai

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: To evaluate technical issues and clinical outcomes after postoperative volumetric-modulated arc therapy (VMAT) in two cases of malignant lacrimal gland cancer. Patients & methods: Patients were treated by postoperative VMAT and post-treatment clinical outcomes were followed-up to 18 months. Results: Dosimetric results were acceptable and acute toxicity was manageable in both patients. No evidence of disease was found at latest follow-up. One patient underwent corneal transplant for central corneal ulceration, experiencing reduction of visual acuity. Conclusion: Postoperative VMAT for treatment of lacrimal gland tumors offers improved outcome, with manageable side effects. In the context of photon beam radiotherapy, VMAT emerged as a valuable treatment option for these malignant tumors.

Original languageEnglish
Pages (from-to)2111-2120
Number of pages10
JournalFuture Oncology
Volume10
Issue number14
DOIs
Publication statusPublished - Nov 1 2014

Keywords

  • adenoid cystic carcinoma
  • carcinoma ex pleomorphic adenoma
  • dosimetric evaluation
  • lacrimal gland tumor
  • postoperative intensity-modulated radiation therapy
  • treatment planning
  • VMAT

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Medicine(all)

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