Postpartum haemorrhage in a woman with essential thrombocythemia carrying calreticulin mutation

a case report

Research output: Contribution to journalArticle

Abstract

Coagulation disorder associated with essential thrombocythemia may exacerbate the prothrombotic state physiologically occurring during pregnancy. We report a case of a severe postpartum haemorrhage in a 35-year-old woman previously diagnosed with essential thrombocythemia and carrying the somatic calreticulin mutation. She was referred to our Thrombosis and Haemostasis Unit for pregnancy management. A treatment with low-dose aspirin was prescribed until the labour started, as the platelets count raised above 1000?×?10/l. At the time of bleeding, no residual placenta was detected at the revision of the uterine cavity.Although the postpartum is a high-risk period for thrombotic events, we have to carefully evaluate in women with essential thrombocythemia the likelihood of developing a hemorrhagic complication.

Original languageEnglish
JournalBlood Coagulation and Fibrinolysis
DOIs
Publication statusAccepted/In press - Dec 8 2015

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Calreticulin
Essential Thrombocythemia
Postpartum Hemorrhage
Mutation
Pregnancy
Bleeding Time
Hemostasis
Platelet Count
Postpartum Period
Placenta
Aspirin
Thrombosis
Therapeutics

ASJC Scopus subject areas

  • Hematology

Cite this

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abstract = "Coagulation disorder associated with essential thrombocythemia may exacerbate the prothrombotic state physiologically occurring during pregnancy. We report a case of a severe postpartum haemorrhage in a 35-year-old woman previously diagnosed with essential thrombocythemia and carrying the somatic calreticulin mutation. She was referred to our Thrombosis and Haemostasis Unit for pregnancy management. A treatment with low-dose aspirin was prescribed until the labour started, as the platelets count raised above 1000?×?10/l. At the time of bleeding, no residual placenta was detected at the revision of the uterine cavity.Although the postpartum is a high-risk period for thrombotic events, we have to carefully evaluate in women with essential thrombocythemia the likelihood of developing a hemorrhagic complication.",
author = "Michela Villani and Donatella Colaizzo and Tiscia, {Giovanni L.} and Elena Chinni and Carl’Antonio Bodenizza and Nicola Cascavilla and Elvira Grandone",
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AU - Villani, Michela

AU - Colaizzo, Donatella

AU - Tiscia, Giovanni L.

AU - Chinni, Elena

AU - Bodenizza, Carl’Antonio

AU - Cascavilla, Nicola

AU - Grandone, Elvira

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