Monitoraggio di mioglobinemia post-partum nei neonati. Correlazione con la funzionalità renale nelle prime 48 ore di vita.

Translated title of the contribution: Postpartum myoglobin blood monitoring in newborns. Correlations with renal function in the first 48 hours of life

R. Rizzardi, S. Castelli, C. Porta, F. Vitali, M. Minerva, M. E. Della Marta, M. Raimondi

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Myoglobin is a muscular tissue protein, and it is a very early damage index. As the newborn "thin mass" is less than that of the adult and knowing the renal dynamics of this protein clearance, the authors have analyzed the correlation between myoglobinemia and transitory renal failure, which is frequently present in newborns with fetal distress. METHODS: We examined a random population of 56 newborns (33 eutocic deliveries 14 caeserotomy, 9 various degrees of fetal distress) to which, after having had the parents' informed consent, the microsamples pattern was fixed at 0, 6, 12, 24, 48 hours from birth at the same time of ordinary exams to gauge: myoglobin with nephelometric method, CPK, creatininemia, azotemia and transaminase. The same exams were camed out on the mother at the beginning of labor and after delivery. RESULTS: We found that the placenta is not permeable to mother myoglobin, at the sixth hour from birth we have the highest value, while CPK is lower to increase, myoglobinemia associated with myoglobin variations. CONCLUSIONS: Myoglobinemia might be monitored to prevent distressed newborns from transitory renal tubular defect, justifying forced diuresis and urinary alkalosis.

Translated title of the contributionPostpartum myoglobin blood monitoring in newborns. Correlations with renal function in the first 48 hours of life
Original languageItalian
Pages (from-to)127-131
Number of pages5
JournalMinerva Anestesiologica
Volume63
Issue number4
Publication statusPublished - Apr 1997

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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