Postpartum relapses increase the risk of disability progression in multiple sclerosis: the role of disease modifying drugs.

Emilio Portaccio, Angelo Ghezzi, Bahia Hakiki, Andrea Sturchio, Vittorio Martinelli, Lucia Moiola, Francesco Patti, Gian Luigi Mancardi, Claudio Solaro, Maria Rosaria Tola, Carlo Pozzilli, Laura De Giglio, Rocco Totaro, Alessandra Lugaresi, Giovanna De Luca, Damiano Paolicelli, Maria Giovanna Marrosu, Giancarlo Comi, Maria Trojano, Maria Pia AmatoGroup of the Italian Neurological Society Study Group of the Italian Neurological Society

Research output: Contribution to journalArticle

Abstract

To assess relapses, disability progression and the role of disease modifying drugs (DMDs) in the year after delivery in women with multiple sclerosis (MS). We prospectively followed-up pregnancies occurring between 2002 and 2008 in women with MS, recruited from 21 Italian MS centres. The risk of relapses and disability progression in the year after delivery was assessed using time-dependent Cox regression analysis. 350 out of 423 pregnancies were assessed (pregnancies not resulting in live birth and with a postpartum follow-up period shorter than 1 year were excluded from the analysis). 148 patients (42.3%) had at least one relapse in the year after delivery. An Expanded Disability Status Scale (EDSS) score at conception ≥2.0 (HR=1.4; 95% CI 1.1 to 2.0; p=0.046) and a higher number of relapses before (HR=1.5; 95% CI 1.2 to 1.8; p

Original languageEnglish
Pages (from-to)845-850
Number of pages6
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume85
Issue number8
Publication statusPublished - 2014

Fingerprint

Postpartum Period
Multiple Sclerosis
Recurrence
Pharmaceutical Preparations
Pregnancy
Live Birth
Disease Progression
Regression Analysis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Portaccio, E., Ghezzi, A., Hakiki, B., Sturchio, A., Martinelli, V., Moiola, L., ... Study Group of the Italian Neurological Society, G. O. T. I. N. S. (2014). Postpartum relapses increase the risk of disability progression in multiple sclerosis: the role of disease modifying drugs. Journal of Neurology, Neurosurgery and Psychiatry, 85(8), 845-850.

Postpartum relapses increase the risk of disability progression in multiple sclerosis : the role of disease modifying drugs. / Portaccio, Emilio; Ghezzi, Angelo; Hakiki, Bahia; Sturchio, Andrea; Martinelli, Vittorio; Moiola, Lucia; Patti, Francesco; Mancardi, Gian Luigi; Solaro, Claudio; Tola, Maria Rosaria; Pozzilli, Carlo; De Giglio, Laura; Totaro, Rocco; Lugaresi, Alessandra; De Luca, Giovanna; Paolicelli, Damiano; Marrosu, Maria Giovanna; Comi, Giancarlo; Trojano, Maria; Amato, Maria Pia; Study Group of the Italian Neurological Society, Group of the Italian Neurological Society.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 85, No. 8, 2014, p. 845-850.

Research output: Contribution to journalArticle

Portaccio, E, Ghezzi, A, Hakiki, B, Sturchio, A, Martinelli, V, Moiola, L, Patti, F, Mancardi, GL, Solaro, C, Tola, MR, Pozzilli, C, De Giglio, L, Totaro, R, Lugaresi, A, De Luca, G, Paolicelli, D, Marrosu, MG, Comi, G, Trojano, M, Amato, MP & Study Group of the Italian Neurological Society, GOTINS 2014, 'Postpartum relapses increase the risk of disability progression in multiple sclerosis: the role of disease modifying drugs.', Journal of Neurology, Neurosurgery and Psychiatry, vol. 85, no. 8, pp. 845-850.
Portaccio, Emilio ; Ghezzi, Angelo ; Hakiki, Bahia ; Sturchio, Andrea ; Martinelli, Vittorio ; Moiola, Lucia ; Patti, Francesco ; Mancardi, Gian Luigi ; Solaro, Claudio ; Tola, Maria Rosaria ; Pozzilli, Carlo ; De Giglio, Laura ; Totaro, Rocco ; Lugaresi, Alessandra ; De Luca, Giovanna ; Paolicelli, Damiano ; Marrosu, Maria Giovanna ; Comi, Giancarlo ; Trojano, Maria ; Amato, Maria Pia ; Study Group of the Italian Neurological Society, Group of the Italian Neurological Society. / Postpartum relapses increase the risk of disability progression in multiple sclerosis : the role of disease modifying drugs. In: Journal of Neurology, Neurosurgery and Psychiatry. 2014 ; Vol. 85, No. 8. pp. 845-850.
@article{e78572ffbff946d9bc2716f35ac5bd0c,
title = "Postpartum relapses increase the risk of disability progression in multiple sclerosis: the role of disease modifying drugs.",
abstract = "To assess relapses, disability progression and the role of disease modifying drugs (DMDs) in the year after delivery in women with multiple sclerosis (MS). We prospectively followed-up pregnancies occurring between 2002 and 2008 in women with MS, recruited from 21 Italian MS centres. The risk of relapses and disability progression in the year after delivery was assessed using time-dependent Cox regression analysis. 350 out of 423 pregnancies were assessed (pregnancies not resulting in live birth and with a postpartum follow-up period shorter than 1 year were excluded from the analysis). 148 patients (42.3{\%}) had at least one relapse in the year after delivery. An Expanded Disability Status Scale (EDSS) score at conception ≥2.0 (HR=1.4; 95{\%} CI 1.1 to 2.0; p=0.046) and a higher number of relapses before (HR=1.5; 95{\%} CI 1.2 to 1.8; p",
author = "Emilio Portaccio and Angelo Ghezzi and Bahia Hakiki and Andrea Sturchio and Vittorio Martinelli and Lucia Moiola and Francesco Patti and Mancardi, {Gian Luigi} and Claudio Solaro and Tola, {Maria Rosaria} and Carlo Pozzilli and {De Giglio}, Laura and Rocco Totaro and Alessandra Lugaresi and {De Luca}, Giovanna and Damiano Paolicelli and Marrosu, {Maria Giovanna} and Giancarlo Comi and Maria Trojano and Amato, {Maria Pia} and {Study Group of the Italian Neurological Society}, {Group of the Italian Neurological Society}",
year = "2014",
language = "English",
volume = "85",
pages = "845--850",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "8",

}

TY - JOUR

T1 - Postpartum relapses increase the risk of disability progression in multiple sclerosis

T2 - the role of disease modifying drugs.

AU - Portaccio, Emilio

AU - Ghezzi, Angelo

AU - Hakiki, Bahia

AU - Sturchio, Andrea

AU - Martinelli, Vittorio

AU - Moiola, Lucia

AU - Patti, Francesco

AU - Mancardi, Gian Luigi

AU - Solaro, Claudio

AU - Tola, Maria Rosaria

AU - Pozzilli, Carlo

AU - De Giglio, Laura

AU - Totaro, Rocco

AU - Lugaresi, Alessandra

AU - De Luca, Giovanna

AU - Paolicelli, Damiano

AU - Marrosu, Maria Giovanna

AU - Comi, Giancarlo

AU - Trojano, Maria

AU - Amato, Maria Pia

AU - Study Group of the Italian Neurological Society, Group of the Italian Neurological Society

PY - 2014

Y1 - 2014

N2 - To assess relapses, disability progression and the role of disease modifying drugs (DMDs) in the year after delivery in women with multiple sclerosis (MS). We prospectively followed-up pregnancies occurring between 2002 and 2008 in women with MS, recruited from 21 Italian MS centres. The risk of relapses and disability progression in the year after delivery was assessed using time-dependent Cox regression analysis. 350 out of 423 pregnancies were assessed (pregnancies not resulting in live birth and with a postpartum follow-up period shorter than 1 year were excluded from the analysis). 148 patients (42.3%) had at least one relapse in the year after delivery. An Expanded Disability Status Scale (EDSS) score at conception ≥2.0 (HR=1.4; 95% CI 1.1 to 2.0; p=0.046) and a higher number of relapses before (HR=1.5; 95% CI 1.2 to 1.8; p

AB - To assess relapses, disability progression and the role of disease modifying drugs (DMDs) in the year after delivery in women with multiple sclerosis (MS). We prospectively followed-up pregnancies occurring between 2002 and 2008 in women with MS, recruited from 21 Italian MS centres. The risk of relapses and disability progression in the year after delivery was assessed using time-dependent Cox regression analysis. 350 out of 423 pregnancies were assessed (pregnancies not resulting in live birth and with a postpartum follow-up period shorter than 1 year were excluded from the analysis). 148 patients (42.3%) had at least one relapse in the year after delivery. An Expanded Disability Status Scale (EDSS) score at conception ≥2.0 (HR=1.4; 95% CI 1.1 to 2.0; p=0.046) and a higher number of relapses before (HR=1.5; 95% CI 1.2 to 1.8; p

UR - http://www.scopus.com/inward/record.url?scp=84906572865&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906572865&partnerID=8YFLogxK

M3 - Article

C2 - 24403285

VL - 85

SP - 845

EP - 850

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 8

ER -