Postpartum relapses increase the risk of disability progression in multiple sclerosis: the role of disease modifying drugs.

Emilio Portaccio, Angelo Ghezzi, Bahia Hakiki, Andrea Sturchio, Vittorio Martinelli, Lucia Moiola, Francesco Patti, Gian Luigi Mancardi, Claudio Solaro, Maria Rosaria Tola, Carlo Pozzilli, Laura De Giglio, Rocco Totaro, Alessandra Lugaresi, Giovanna De Luca, Damiano Paolicelli, Maria Giovanna Marrosu, Giancarlo Comi, Maria Trojano, Maria Pia AmatoGroup of the Italian Neurological Society Study Group of the Italian Neurological Society

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Abstract

To assess relapses, disability progression and the role of disease modifying drugs (DMDs) in the year after delivery in women with multiple sclerosis (MS). We prospectively followed-up pregnancies occurring between 2002 and 2008 in women with MS, recruited from 21 Italian MS centres. The risk of relapses and disability progression in the year after delivery was assessed using time-dependent Cox regression analysis. 350 out of 423 pregnancies were assessed (pregnancies not resulting in live birth and with a postpartum follow-up period shorter than 1 year were excluded from the analysis). 148 patients (42.3%) had at least one relapse in the year after delivery. An Expanded Disability Status Scale (EDSS) score at conception ≥2.0 (HR=1.4; 95% CI 1.1 to 2.0; p=0.046) and a higher number of relapses before (HR=1.5; 95% CI 1.2 to 1.8; p

Original languageEnglish
Pages (from-to)845-850
Number of pages6
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume85
Issue number8
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Medicine(all)

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    Portaccio, E., Ghezzi, A., Hakiki, B., Sturchio, A., Martinelli, V., Moiola, L., Patti, F., Mancardi, G. L., Solaro, C., Tola, M. R., Pozzilli, C., De Giglio, L., Totaro, R., Lugaresi, A., De Luca, G., Paolicelli, D., Marrosu, M. G., Comi, G., Trojano, M., ... Study Group of the Italian Neurological Society, G. O. T. I. N. S. (2014). Postpartum relapses increase the risk of disability progression in multiple sclerosis: the role of disease modifying drugs. Journal of Neurology, Neurosurgery and Psychiatry, 85(8), 845-850.