Postpartum relapses increase the risk of disability progression in multiple sclerosis: The role of disease modifying drugs

Emilio Portaccio, Angelo Ghezzi, Bahia Hakiki, Andrea Sturchio, Vittorio Martinelli, Lucia Moiola, Francesco Patti, Gian Luigi Mancardi, Claudio Solaro, Maria Rosaria Tola, Carlo Pozzilli, Laura De Giglio, Rocco Totaro, Alessandra Lugaresi, Giovanna De Luca, Damiano Paolicelli, Maria Giovanna Marrosu, Giancarlo Comi, Maria Trojano, Maria Pia Amato

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Objective: To assess relapses, disability progression and the role of disease modifying drugs (DMDs) in the year after delivery in women with multiple sclerosis (MS). Methods: We prospectively followed-up pregnancies occurring between 2002 and 2008 in women with MS, recruited from 21 Italian MS centres. The risk of relapses and disability progression in the year after delivery was assessed using time-dependent Cox regression analysis. Results: 350 out of 423 pregnancies were assessed (pregnancies not resulting in live birth and with a postpartum follow-up period shorter than 1 year were excluded from the analysis). 148 patients (42.3%) had at least one relapse in the year after delivery. An Expanded Disability Status Scale (EDSS) score at conception ≥2.0 (HR=1.4; 95% CI 1.1 to 2.0; p=0.046) and a higher number of relapses before (HR=1.5; 95% CI 1.2 to 1.8; p

Original languageEnglish
Pages (from-to)846-851
Number of pages6
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume85
Issue number8
DOIs
Publication statusPublished - 2014

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Postpartum Period
Multiple Sclerosis
Recurrence
Pharmaceutical Preparations
Pregnancy
Live Birth
Disease Progression
Regression Analysis
Drugs
Relapse
Progression

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Surgery
  • Arts and Humanities (miscellaneous)

Cite this

Postpartum relapses increase the risk of disability progression in multiple sclerosis : The role of disease modifying drugs. / Portaccio, Emilio; Ghezzi, Angelo; Hakiki, Bahia; Sturchio, Andrea; Martinelli, Vittorio; Moiola, Lucia; Patti, Francesco; Mancardi, Gian Luigi; Solaro, Claudio; Tola, Maria Rosaria; Pozzilli, Carlo; De Giglio, Laura; Totaro, Rocco; Lugaresi, Alessandra; De Luca, Giovanna; Paolicelli, Damiano; Marrosu, Maria Giovanna; Comi, Giancarlo; Trojano, Maria; Amato, Maria Pia.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 85, No. 8, 2014, p. 846-851.

Research output: Contribution to journalArticle

Portaccio, E, Ghezzi, A, Hakiki, B, Sturchio, A, Martinelli, V, Moiola, L, Patti, F, Mancardi, GL, Solaro, C, Tola, MR, Pozzilli, C, De Giglio, L, Totaro, R, Lugaresi, A, De Luca, G, Paolicelli, D, Marrosu, MG, Comi, G, Trojano, M & Amato, MP 2014, 'Postpartum relapses increase the risk of disability progression in multiple sclerosis: The role of disease modifying drugs', Journal of Neurology, Neurosurgery and Psychiatry, vol. 85, no. 8, pp. 846-851. https://doi.org/10.1136/jnnp-2013-306054
Portaccio, Emilio ; Ghezzi, Angelo ; Hakiki, Bahia ; Sturchio, Andrea ; Martinelli, Vittorio ; Moiola, Lucia ; Patti, Francesco ; Mancardi, Gian Luigi ; Solaro, Claudio ; Tola, Maria Rosaria ; Pozzilli, Carlo ; De Giglio, Laura ; Totaro, Rocco ; Lugaresi, Alessandra ; De Luca, Giovanna ; Paolicelli, Damiano ; Marrosu, Maria Giovanna ; Comi, Giancarlo ; Trojano, Maria ; Amato, Maria Pia. / Postpartum relapses increase the risk of disability progression in multiple sclerosis : The role of disease modifying drugs. In: Journal of Neurology, Neurosurgery and Psychiatry. 2014 ; Vol. 85, No. 8. pp. 846-851.
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AU - Portaccio, Emilio

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AU - Sturchio, Andrea

AU - Martinelli, Vittorio

AU - Moiola, Lucia

AU - Patti, Francesco

AU - Mancardi, Gian Luigi

AU - Solaro, Claudio

AU - Tola, Maria Rosaria

AU - Pozzilli, Carlo

AU - De Giglio, Laura

AU - Totaro, Rocco

AU - Lugaresi, Alessandra

AU - De Luca, Giovanna

AU - Paolicelli, Damiano

AU - Marrosu, Maria Giovanna

AU - Comi, Giancarlo

AU - Trojano, Maria

AU - Amato, Maria Pia

PY - 2014

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N2 - Objective: To assess relapses, disability progression and the role of disease modifying drugs (DMDs) in the year after delivery in women with multiple sclerosis (MS). Methods: We prospectively followed-up pregnancies occurring between 2002 and 2008 in women with MS, recruited from 21 Italian MS centres. The risk of relapses and disability progression in the year after delivery was assessed using time-dependent Cox regression analysis. Results: 350 out of 423 pregnancies were assessed (pregnancies not resulting in live birth and with a postpartum follow-up period shorter than 1 year were excluded from the analysis). 148 patients (42.3%) had at least one relapse in the year after delivery. An Expanded Disability Status Scale (EDSS) score at conception ≥2.0 (HR=1.4; 95% CI 1.1 to 2.0; p=0.046) and a higher number of relapses before (HR=1.5; 95% CI 1.2 to 1.8; p

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