Postprandial cell inflammatory response to a standardised fatty meal in subjects at different degree of cardiovascular risk

Chiara Tamburrelli, Francesco Gianfagna, Marco D'Imperio, Amalia de Curtis, Domenico Rotilio, Licia Iacoviello, Giovanni de Gaetano, Maria Benedetta Donati, Chiara Cerletti

Research output: Contribution to journalArticle

Abstract

A fatty meal may represent a challenge of in vivo acute inflammatory reaction. We evaluated the acute effects of a standardised fatty meal administration on leukocytes and platelets and on their interactions on 61 subjects at different degree of cardiovascular risk, without any clinical event. Before and 2 hours after a fatty meal, blood cells were counted and markers of leukocyte (intracellular myeloperoxidase [MPO] and Mac-1) and platelet (P-selectin and microparticles) activation and mixed platelet-leukocyte conjugates measured by flow-cytometry. After the fatty meal, both white blood cell and platelet count significantly increased, more markedly in subjects with lower cardiovascular risk score. Mac-1 expression too increased (from 32.2 ± 27.2% to 45.6 ± 29.0%, p=0.0016), while MPO decreased (from 83.1 ± 16.3% to 64.5 ± 23.1%, p

Original languageEnglish
Pages (from-to)530-537
Number of pages8
JournalThrombosis and Haemostasis
Volume107
Issue number3
DOIs
Publication statusPublished - Mar 2012

Keywords

  • Acute cell inflammatory response
  • Cardiovascular risk
  • Fatty meal
  • Gender
  • Platelet and leukocyte activation

ASJC Scopus subject areas

  • Hematology

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