TY - JOUR
T1 - Postprandial cell inflammatory response to a standardised fatty meal in subjects at different degree of cardiovascular risk
AU - Tamburrelli, Chiara
AU - Gianfagna, Francesco
AU - D'Imperio, Marco
AU - de Curtis, Amalia
AU - Rotilio, Domenico
AU - Iacoviello, Licia
AU - de Gaetano, Giovanni
AU - Donati, Maria Benedetta
AU - Cerletti, Chiara
PY - 2012/3
Y1 - 2012/3
N2 - A fatty meal may represent a challenge of in vivo acute inflammatory reaction. We evaluated the acute effects of a standardised fatty meal administration on leukocytes and platelets and on their interactions on 61 subjects at different degree of cardiovascular risk, without any clinical event. Before and 2 hours after a fatty meal, blood cells were counted and markers of leukocyte (intracellular myeloperoxidase [MPO] and Mac-1) and platelet (P-selectin and microparticles) activation and mixed platelet-leukocyte conjugates measured by flow-cytometry. After the fatty meal, both white blood cell and platelet count significantly increased, more markedly in subjects with lower cardiovascular risk score. Mac-1 expression too increased (from 32.2 ± 27.2% to 45.6 ± 29.0%, p=0.0016), while MPO decreased (from 83.1 ± 16.3% to 64.5 ± 23.1%, p
AB - A fatty meal may represent a challenge of in vivo acute inflammatory reaction. We evaluated the acute effects of a standardised fatty meal administration on leukocytes and platelets and on their interactions on 61 subjects at different degree of cardiovascular risk, without any clinical event. Before and 2 hours after a fatty meal, blood cells were counted and markers of leukocyte (intracellular myeloperoxidase [MPO] and Mac-1) and platelet (P-selectin and microparticles) activation and mixed platelet-leukocyte conjugates measured by flow-cytometry. After the fatty meal, both white blood cell and platelet count significantly increased, more markedly in subjects with lower cardiovascular risk score. Mac-1 expression too increased (from 32.2 ± 27.2% to 45.6 ± 29.0%, p=0.0016), while MPO decreased (from 83.1 ± 16.3% to 64.5 ± 23.1%, p
KW - Acute cell inflammatory response
KW - Cardiovascular risk
KW - Fatty meal
KW - Gender
KW - Platelet and leukocyte activation
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U2 - 10.1160/TH11-09-0674
DO - 10.1160/TH11-09-0674
M3 - Article
C2 - 22274593
AN - SCOPUS:84857743519
VL - 107
SP - 530
EP - 537
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
SN - 0340-6245
IS - 3
ER -