Postprandial glucose regulation and diabetic complications

Antonio Ceriello, Markolf Hanefeld, Lawrence Leiter, Louis Monnier, Alan Moses, David Owens, Naoko Tajima, Jaakko Tuomilehto

Research output: Contribution to journalArticlepeer-review

Abstract

Atherosclerotic disease accounts for much of the increased mortality and morbidity associated with type 2 diabetes. Epidemiological studies support the potential of improved glycemic control to reduce cardiovascular complications. An association between glycosylated hemoglobin (HbA1c) level and the risk for cardiovascular complications has frequently been reported. Most epidemiological data implicate postprandial hyperglycemia in the development of cardiovascular disease, whereas the link between fasting glycemia and diabetic complications is inconclusive. Moreover, in many studies, postprandial glycemia is a better predictor of cardiovascular risk than HbA1c level. Postprandial glucose may have a direct toxic effect on the vascular endothelium, mediated by oxidative stress that is independent of other cardiovascular risk factors such as hyperlipidemia. Postprandial hyperglycemia also may exert its effects through its substantial contribution to total glycemic exposure. The present review examines the hypothesis that controlling postprandial glucose level is an important strategy in the prevention of cardiovascular complications associated with diabetes.

Original languageEnglish
Pages (from-to)2090-2095
Number of pages6
JournalArchives of Internal Medicine
Volume164
Issue number19
DOIs
Publication statusPublished - Oct 25 2004

ASJC Scopus subject areas

  • Internal Medicine

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