Abstract
Type 2 diabetes is primarily a disorder of post-prandial glucose regulation, characterized by a gradual decline in insulin secretion in response to nutrient loads. Despite this, physicians continue to rely on fasting blood glucose and glycosylated haemoglobin (HbA1c) to guide management. There is a linear relationship between the risk of cardiovascular death and the 2-hour oral glucose tolerance test (OGTT). A recent study demonstrated that postprandial hyperglycaemia is an independent risk factor for cardiovascular disease in type 2 diabetes. Also, several intervention studies have shown that treating post-prandial hyperglycaemia may reduce the incidence of new cardiovascular events. Evidence supports the hypothesis that post-prandial hyperglycaemia may lead to cardiovascular disease through the generation of oxidative stress. Furthermore, clinical data suggest that post-prandial hyperglycaemia is a common phenomenon, even in patients who may be considered as having good metabolic control.
Original language | English |
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Pages (from-to) | 363-373 |
Number of pages | 11 |
Journal | Diabetes, Stoffwechsel und Herz |
Volume | 17 |
Issue number | 5 |
Publication status | Published - Sep 20 2008 |
Keywords
- Cardiovascular disease
- Cardiovascular risk
- Postprandial hyperglycaemia
- Type 2 diabetes
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Internal Medicine