Postprandial hyperglycaemia: A new risk factor for cardiovascular disease

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Abstract

Type 2 diabetes is primarily a disorder of post-prandial glucose regulation, characterized by a gradual decline in insulin secretion in response to nutrient loads. Despite this, physicians continue to rely on fasting blood glucose and glycosylated haemoglobin (HbA1c) to guide management. There is a linear relationship between the risk of cardiovascular death and the 2-hour oral glucose tolerance test (OGTT). A recent study demonstrated that postprandial hyperglycaemia is an independent risk factor for cardiovascular disease in type 2 diabetes. Also, several intervention studies have shown that treating post-prandial hyperglycaemia may reduce the incidence of new cardiovascular events. Evidence supports the hypothesis that post-prandial hyperglycaemia may lead to cardiovascular disease through the generation of oxidative stress. Furthermore, clinical data suggest that post-prandial hyperglycaemia is a common phenomenon, even in patients who may be considered as having good metabolic control.

Original languageEnglish
Pages (from-to)363-373
Number of pages11
JournalDiabetes, Stoffwechsel und Herz
Volume17
Issue number5
Publication statusPublished - Sep 20 2008

Keywords

  • Cardiovascular disease
  • Cardiovascular risk
  • Postprandial hyperglycaemia
  • Type 2 diabetes

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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