Postprandial hyperglycaemia and cardiovascular complications of diabetes: An update

Antonio Ceriello, Jamie Davidson, Markolf Hanefeld, Lawrence Leiter, Louis Monnier, David Owens, Naoko Tajima, Jaakko Tuomilehto

Research output: Contribution to journalArticlepeer-review

Abstract

Type 2 diabetes is characterised by a gradual decline in insulin secretion in response to nutrient loads; hence, it is primarily a disorder of postprandial glucose (PPG) regulation. However, physicians continue to rely on fasting plasma glucose (FPG) and glycosylated haemoglobin (HbA1c) levels as indicators for disease management. There is a linear relationship between the risk of cardiovascular disease (CVD) and the two-hour oral glucose tolerance test (OGTT), while a recent study confirms postprandial hyperglycaemia as an independent risk factor for CVD in type 2 diabetes. At the same time, several intervention studies have shown that treating postprandial hyperglycaemia may reduce the incidence of new cardiovascular events. Evidence supports the hypothesis that postprandial hyperglycaemia may be linked to CVD through the generation of oxidative stress. Furthermore, clinical data suggest that postprandial hyperglycaemia is a common phenomenon, even in patients who may be considered in 'good metabolic control'. Therefore, in addition to HbA1c and FPG, physicians should consider monitoring and targeting PPG in patients with type 2 diabetes.

Original languageEnglish
Pages (from-to)453-456
Number of pages4
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume16
Issue number7
DOIs
Publication statusPublished - Oct 2006

Keywords

  • Diabetic complications
  • Postprandial hyperglycaemia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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