Postprandial triglyceride profile after a standardized oral fat load is altered in growth hormone (GH)-deficient adult patients and is not improved after short-term GH replacement therapy

Mario Perotti, Andrea Caumo, Amelia Brunani, Nadia Cambiaghi, Marco Casati, Massimo Scacchi, Silvia Perra, Cristina Rocco, Giuseppe Mancia, Guido Grassi, Francesco Cavagnini, Angela Ida Pincelli

Research output: Contribution to journalArticle

Abstract

Objective Adult growth hormone deficiency (GHD) has detrimental effects on metabolic profile, leading to an increased cardiovascular mortality and morbidity. Above all, disturbance in postprandial triglyceride metabolism is of major concern because of the crucial role of triglyceride-rich lipoproteins in atherogenesis. The majority of previous studies on GH replacement have shown favourable changes in the fasting lipid profile. Aim of this study is to investigate whether this beneficial effect is exerted also on postprandial triglyceride (TG) metabolism. Patients and methods We challenged nine GHD patients with a standardized fat loading meal at baseline and after 6 months of GH replacement therapy. Nine healthy control subjects were similarly tested under baseline conditions. Blood samples were obtained before and up to 8 h after fat loading for serum lipid analysis. Results We found that GHD patients with fasting TG level in the normal range (1·29 ± 0·31 mm) had a delayed postprandial TG clearance compared to healthy controls (triglyceride level at 8 h, 3·82 ± 0·83 vs 1 ± 0·06 mm P <0·01), and the postprandial hypertriglyceridaemia was not corrected by 6 months of GH therapy. Conclusions This study has shown for the first time that GHD adult patients have a higher postprandial triglyceridaemia compared to healthy controls when challenged by a standardized fat load and that this atherogenic feature is not normalized by short-term GH treatment despite a decrease in visceral fat mass described during the replacement therapy.

Original languageEnglish
Pages (from-to)721-727
Number of pages7
JournalClinical Endocrinology
Volume77
Issue number5
DOIs
Publication statusPublished - Nov 2012

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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