Postprocedural PAI-1 activity is a risk marker of subsequent clinical restenosis in patients both with and without stent implantation after elective balloon PTCA

Domenico Prisco, Sandra Fedi, Emilia Antonucci, Monia Capanni, Ludia Chiarugi, Marco Chioccioli, Massimiliano Falai, Cristina Giglioli, Rosanna Abbate, Gian Franco Gensini

Research output: Contribution to journalArticlepeer-review

Abstract

Stent implantation after balloon dilation of coronary arteries has improved clinical prognosis in patients undergoing transluminal coronary angioplasty (PTCA), but late restenosis remains a relevant problem. A previous study has indicated that PAI-1 activity changes immediately after PTCA without stent implantation are predictive of clinical restenosis. The present study was aimed to investigate the early PAI-1 changes and fibrin formation in patients undergoing elective PTCA with stent implantation. PAI-1 activity and D-dimer plasma levels were evaluated in two groups of patients (G1 underwent only elective balloon PTCA and G2 underwent elective PTCA with stent implantation) before and after the procedure. At the end of the procedure, PAI-1 activity significantly decreased, while D-dimer levels significantly increased in both groups. Post-PTCA D-dimer levels in the group with stent implantation were significantly higher than in the other group (P

Original languageEnglish
Pages (from-to)181-186
Number of pages6
JournalThrombosis Research
Volume104
Issue number3
DOIs
Publication statusPublished - Nov 1 2001

Keywords

  • Clinical restenosis
  • PAI-1 activity
  • PTCA
  • Stent

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

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