Abstract
Aims and background: Post-irradiation sarcoma (PIS) is a rare, late side effect of radiotherapy and, consequently, its natural history is not well known. For this reason, two cases treated between 1975 and 1990 are described. Case reports: The authors describe one case of malignant fibrous histiocytoma grown in the larynx 111 months after conservative surgery and postoperative radiotherapy, and one case of soft tissue sarcoma developed in the oral cavity 72 months after radical interstitial low dose rate brachytherapy. Both patients had chronic distress of the soft tissues after the primary treatment. The patients are alive and well respectively at 94 and 18 months from salvage surgery. Discussion: The PIS of the head and neck region is a rare event, usually with a bad prognosis. An improvement in results could be possible with early diagnosis, followed by a timely excision, when anatomically possible. As the chronic suffering of the irradiated tissues may increase the risk of PIS, a longer and more frequent follow-up is advisable in these cases.
| Original language | English |
|---|---|
| Pages (from-to) | 270-272 |
| Number of pages | 3 |
| Journal | Tumori |
| Volume | 82 |
| Issue number | 3 |
| Publication status | Published - May 1996 |
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Keywords
- head and neck cancer
- post-irradiation sarcoma
- radiotherapy
ASJC Scopus subject areas
- Cancer Research
Cite this
Postradiation sarcoma of head and neck : Report of two cases. / Bonetta, Alberto; Gelli, Maria Carolina; Zini, Giampaolo; Iotti, Cinzia; Barbieri, Verter; Pedroni, Corrado; Armaroli, Luciano.
In: Tumori, Vol. 82, No. 3, 05.1996, p. 270-272.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Postradiation sarcoma of head and neck
T2 - Report of two cases
AU - Bonetta, Alberto
AU - Gelli, Maria Carolina
AU - Zini, Giampaolo
AU - Iotti, Cinzia
AU - Barbieri, Verter
AU - Pedroni, Corrado
AU - Armaroli, Luciano
PY - 1996/5
Y1 - 1996/5
N2 - Aims and background: Post-irradiation sarcoma (PIS) is a rare, late side effect of radiotherapy and, consequently, its natural history is not well known. For this reason, two cases treated between 1975 and 1990 are described. Case reports: The authors describe one case of malignant fibrous histiocytoma grown in the larynx 111 months after conservative surgery and postoperative radiotherapy, and one case of soft tissue sarcoma developed in the oral cavity 72 months after radical interstitial low dose rate brachytherapy. Both patients had chronic distress of the soft tissues after the primary treatment. The patients are alive and well respectively at 94 and 18 months from salvage surgery. Discussion: The PIS of the head and neck region is a rare event, usually with a bad prognosis. An improvement in results could be possible with early diagnosis, followed by a timely excision, when anatomically possible. As the chronic suffering of the irradiated tissues may increase the risk of PIS, a longer and more frequent follow-up is advisable in these cases.
AB - Aims and background: Post-irradiation sarcoma (PIS) is a rare, late side effect of radiotherapy and, consequently, its natural history is not well known. For this reason, two cases treated between 1975 and 1990 are described. Case reports: The authors describe one case of malignant fibrous histiocytoma grown in the larynx 111 months after conservative surgery and postoperative radiotherapy, and one case of soft tissue sarcoma developed in the oral cavity 72 months after radical interstitial low dose rate brachytherapy. Both patients had chronic distress of the soft tissues after the primary treatment. The patients are alive and well respectively at 94 and 18 months from salvage surgery. Discussion: The PIS of the head and neck region is a rare event, usually with a bad prognosis. An improvement in results could be possible with early diagnosis, followed by a timely excision, when anatomically possible. As the chronic suffering of the irradiated tissues may increase the risk of PIS, a longer and more frequent follow-up is advisable in these cases.
KW - head and neck cancer
KW - post-irradiation sarcoma
KW - radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=0029949628&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029949628&partnerID=8YFLogxK
M3 - Article
C2 - 8693611
AN - SCOPUS:0029949628
VL - 82
SP - 270
EP - 272
JO - Tumori
JF - Tumori
SN - 0300-8916
IS - 3
ER -