Postsplenectomy type-1 hypersensitivity response

A correlation between IL-4 and IgE serum levels

Stefano Miniello, Graziana Cristallo, Mario Testini, Mario Giosuè Balzanelli, Rinaldo Marzaioli, Pietro Venezia, Germana Lissidini, Dino Petrozza, Michele Nacchiero

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Authors demonstrated the presence of allergic manifestations in splenectomized patients following traumatic rupture of this organ. In particular, allergic diathesis, as supported by serum IgE increase, was exclusively found in patients with preserved T helper (h)-2 lymphocyte function. Th-2 function was monitored by measuring serum levels of interleukin (IL)-4, a cytokine involved in IgE synthesis. On the opposite, in splenectomized individuals with a reduced Th-2 function as supported by lower IL-4 serum levels, no IgE increase and allergic manifestations were detectable. On these grounds, authors hypothesize that allergic manifestations may be correlated to splenectomy since its exeresis may favor the persistence of antigens in the blood. Consequentially, in patients with a preserved Th-2 function, antigenic overload may lead to IgE increase and allergy onset.

Original languageEnglish
Pages (from-to)71-77
Number of pages7
JournalImmunopharmacology and Immunotoxicology
Volume30
Issue number1
DOIs
Publication statusPublished - Mar 2008

Fingerprint

Immediate Hypersensitivity
Interleukin-4
Immunoglobulin E
Serum
Allergies
Lymphocytes
Disease Susceptibility
Splenectomy
Rupture
Hypersensitivity
Blood
Cytokines
Antigens

Keywords

  • Allergy
  • IgE
  • Interleukin-4
  • Splenectomy
  • Trauma

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Miniello, S., Cristallo, G., Testini, M., Balzanelli, M. G., Marzaioli, R., Venezia, P., ... Nacchiero, M. (2008). Postsplenectomy type-1 hypersensitivity response: A correlation between IL-4 and IgE serum levels. Immunopharmacology and Immunotoxicology, 30(1), 71-77. https://doi.org/10.1080/08923970701812597

Postsplenectomy type-1 hypersensitivity response : A correlation between IL-4 and IgE serum levels. / Miniello, Stefano; Cristallo, Graziana; Testini, Mario; Balzanelli, Mario Giosuè; Marzaioli, Rinaldo; Venezia, Pietro; Lissidini, Germana; Petrozza, Dino; Nacchiero, Michele.

In: Immunopharmacology and Immunotoxicology, Vol. 30, No. 1, 03.2008, p. 71-77.

Research output: Contribution to journalArticle

Miniello, S, Cristallo, G, Testini, M, Balzanelli, MG, Marzaioli, R, Venezia, P, Lissidini, G, Petrozza, D & Nacchiero, M 2008, 'Postsplenectomy type-1 hypersensitivity response: A correlation between IL-4 and IgE serum levels', Immunopharmacology and Immunotoxicology, vol. 30, no. 1, pp. 71-77. https://doi.org/10.1080/08923970701812597
Miniello, Stefano ; Cristallo, Graziana ; Testini, Mario ; Balzanelli, Mario Giosuè ; Marzaioli, Rinaldo ; Venezia, Pietro ; Lissidini, Germana ; Petrozza, Dino ; Nacchiero, Michele. / Postsplenectomy type-1 hypersensitivity response : A correlation between IL-4 and IgE serum levels. In: Immunopharmacology and Immunotoxicology. 2008 ; Vol. 30, No. 1. pp. 71-77.
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