Postsurgery outcomes in patients with polycythemia vera and essential thrombocythemia: A retrospective survey

Marco Ruggeri, Francesco Rodeghiero, Alberto Tosetto, Giancarlo Castaman, Francesca Scognamiglio, Guido Finazzi, Federica Delaini, Caterina Micò, Alessandro M. Vannucchi, Elisabetta Antonioli, Valerio De Stefano, Tommaso Za, Luigi Gugliotta, Alessia Tieghi, Maria Gabriella Mazzucconi, Cristina Santoro, Tiziano Barbui

Research output: Contribution to journalArticle

Abstract

A multicenter retrospective analysis was performed to estimate the frequency of thrombosis and hemorrhage after surgical procedures in patients with polycythemia vera (PV) and patients with essential thrombocythemia (ET). Data from 105 patients with PV and 150 patients with ET were analyzed, for a total of 311 surgical interventions. An emergency procedure was performed in 25 (8.1%) patients; 194 surgeries were done under general anesthesia, and 21 (23%) of 91 abdominal interventions were done under laparoscopy; 155 (50.1%) were major surgeries. Subcutaneous heparin was administered in 169 (54.3%) of 311 cases and antiplatelet therapy in 48 (15.4%) of 311 case interventions. One hundred eighty-eight (74%) of 255 patients were on cytoreductive therapy before surgery. No events were observed in 259 (83.2%) of 311 procedures during 3 months of follow-up; there were 12 arterial and 12 venous thrombotic events, 23 major and 7 minor hemorrhages, and 5 deaths. Arterial thromboses were more frequent in ET (5.3% vs 1.5%; P = .08), venous events were more frequent in PV (7.7% vs 1.1%; P = .002). There was not a correlation between bleeding episodes and the type of diagnosis, use of antithrombotic prophylaxis, or type of surgery. A high proportion of PV and ET surgeries was complicated by vascular occlusion (7.7%) or by a major hemorrhage (7.3%). Prospective investigations analyzing the optimal prophylaxis in these patients are suggested.

Original languageEnglish
Pages (from-to)666-671
Number of pages6
JournalBlood
Volume111
Issue number2
DOIs
Publication statusPublished - Jan 15 2008

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Essential Thrombocythemia
Polycythemia Vera
Surgery
Hemorrhage
Laparoscopy
Thrombosis
Surgical Blood Loss
Heparin
Surveys and Questionnaires
General Anesthesia
Blood Vessels
Emergencies
Therapeutics

ASJC Scopus subject areas

  • Hematology

Cite this

Ruggeri, M., Rodeghiero, F., Tosetto, A., Castaman, G., Scognamiglio, F., Finazzi, G., ... Barbui, T. (2008). Postsurgery outcomes in patients with polycythemia vera and essential thrombocythemia: A retrospective survey. Blood, 111(2), 666-671. https://doi.org/10.1182/blood-2007-07-102665

Postsurgery outcomes in patients with polycythemia vera and essential thrombocythemia : A retrospective survey. / Ruggeri, Marco; Rodeghiero, Francesco; Tosetto, Alberto; Castaman, Giancarlo; Scognamiglio, Francesca; Finazzi, Guido; Delaini, Federica; Micò, Caterina; Vannucchi, Alessandro M.; Antonioli, Elisabetta; De Stefano, Valerio; Za, Tommaso; Gugliotta, Luigi; Tieghi, Alessia; Mazzucconi, Maria Gabriella; Santoro, Cristina; Barbui, Tiziano.

In: Blood, Vol. 111, No. 2, 15.01.2008, p. 666-671.

Research output: Contribution to journalArticle

Ruggeri, M, Rodeghiero, F, Tosetto, A, Castaman, G, Scognamiglio, F, Finazzi, G, Delaini, F, Micò, C, Vannucchi, AM, Antonioli, E, De Stefano, V, Za, T, Gugliotta, L, Tieghi, A, Mazzucconi, MG, Santoro, C & Barbui, T 2008, 'Postsurgery outcomes in patients with polycythemia vera and essential thrombocythemia: A retrospective survey', Blood, vol. 111, no. 2, pp. 666-671. https://doi.org/10.1182/blood-2007-07-102665
Ruggeri M, Rodeghiero F, Tosetto A, Castaman G, Scognamiglio F, Finazzi G et al. Postsurgery outcomes in patients with polycythemia vera and essential thrombocythemia: A retrospective survey. Blood. 2008 Jan 15;111(2):666-671. https://doi.org/10.1182/blood-2007-07-102665
Ruggeri, Marco ; Rodeghiero, Francesco ; Tosetto, Alberto ; Castaman, Giancarlo ; Scognamiglio, Francesca ; Finazzi, Guido ; Delaini, Federica ; Micò, Caterina ; Vannucchi, Alessandro M. ; Antonioli, Elisabetta ; De Stefano, Valerio ; Za, Tommaso ; Gugliotta, Luigi ; Tieghi, Alessia ; Mazzucconi, Maria Gabriella ; Santoro, Cristina ; Barbui, Tiziano. / Postsurgery outcomes in patients with polycythemia vera and essential thrombocythemia : A retrospective survey. In: Blood. 2008 ; Vol. 111, No. 2. pp. 666-671.
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abstract = "A multicenter retrospective analysis was performed to estimate the frequency of thrombosis and hemorrhage after surgical procedures in patients with polycythemia vera (PV) and patients with essential thrombocythemia (ET). Data from 105 patients with PV and 150 patients with ET were analyzed, for a total of 311 surgical interventions. An emergency procedure was performed in 25 (8.1{\%}) patients; 194 surgeries were done under general anesthesia, and 21 (23{\%}) of 91 abdominal interventions were done under laparoscopy; 155 (50.1{\%}) were major surgeries. Subcutaneous heparin was administered in 169 (54.3{\%}) of 311 cases and antiplatelet therapy in 48 (15.4{\%}) of 311 case interventions. One hundred eighty-eight (74{\%}) of 255 patients were on cytoreductive therapy before surgery. No events were observed in 259 (83.2{\%}) of 311 procedures during 3 months of follow-up; there were 12 arterial and 12 venous thrombotic events, 23 major and 7 minor hemorrhages, and 5 deaths. Arterial thromboses were more frequent in ET (5.3{\%} vs 1.5{\%}; P = .08), venous events were more frequent in PV (7.7{\%} vs 1.1{\%}; P = .002). There was not a correlation between bleeding episodes and the type of diagnosis, use of antithrombotic prophylaxis, or type of surgery. A high proportion of PV and ET surgeries was complicated by vascular occlusion (7.7{\%}) or by a major hemorrhage (7.3{\%}). Prospective investigations analyzing the optimal prophylaxis in these patients are suggested.",
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AU - Castaman, Giancarlo

AU - Scognamiglio, Francesca

AU - Finazzi, Guido

AU - Delaini, Federica

AU - Micò, Caterina

AU - Vannucchi, Alessandro M.

AU - Antonioli, Elisabetta

AU - De Stefano, Valerio

AU - Za, Tommaso

AU - Gugliotta, Luigi

AU - Tieghi, Alessia

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