TY - JOUR
T1 - Postsynaptic autism spectrum disorder genes and synaptic dysfunction
AU - Bonsi, Paola
AU - De Jaco, Antonella
AU - Fasano, Laurent
AU - Gubellini, Paolo
N1 - Funding Information:
This work was partially supported by the Italian Ministry of Health “Ricerca Corrente” (P.B.) and by the French National Research Agency (ANR) “TSHZ3inASD” project grant n° ANR-17-CE16-0030-01 (L.F. and P.G.). The funding sources had no involvement in the design or writing of the report and in the decision to submit the article for publication.
Funding Information:
This work was partially supported by the Italian Ministry of Health ?Ricerca Corrente? (P.B.) and by the French National Research Agency (ANR) ?TSHZ3inASD? project grant n?ANR-17-CE16-0030-01 (L.F. and P.G.). The funding sources had no involvement in the design or writing of the report and in the decision to submit the article for publication.
Publisher Copyright:
© 2021 The Authors
PY - 2022/1
Y1 - 2022/1
N2 - This review provides an overview of the synaptic dysfunction of neuronal circuits and the ensuing behavioral alterations caused by mutations in autism spectrum disorder (ASD)-linked genes directly or indirectly affecting the postsynaptic neuronal compartment. There are plenty of ASD risk genes, that may be broadly grouped into those involved in gene expression regulation (epigenetic regulation and transcription) and genes regulating synaptic activity (neural communication and neurotransmission). Notably, the effects mediated by ASD-associated genes can vary extensively depending on the developmental time and/or subcellular site of expression. Therefore, in order to gain a better understanding of the mechanisms of disruptions in postsynaptic function, an effort to better model ASD in experimental animals is required to improve standardization and increase reproducibility within and among studies. Such an effort holds promise to provide deeper insight into the development of these disorders and to improve the translational value of preclinical studies.
AB - This review provides an overview of the synaptic dysfunction of neuronal circuits and the ensuing behavioral alterations caused by mutations in autism spectrum disorder (ASD)-linked genes directly or indirectly affecting the postsynaptic neuronal compartment. There are plenty of ASD risk genes, that may be broadly grouped into those involved in gene expression regulation (epigenetic regulation and transcription) and genes regulating synaptic activity (neural communication and neurotransmission). Notably, the effects mediated by ASD-associated genes can vary extensively depending on the developmental time and/or subcellular site of expression. Therefore, in order to gain a better understanding of the mechanisms of disruptions in postsynaptic function, an effort to better model ASD in experimental animals is required to improve standardization and increase reproducibility within and among studies. Such an effort holds promise to provide deeper insight into the development of these disorders and to improve the translational value of preclinical studies.
KW - Animal models of ASD
KW - ASD gene expression regulation
KW - Mitochondrial dysfunction
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U2 - 10.1016/j.nbd.2021.105564
DO - 10.1016/j.nbd.2021.105564
M3 - Article
AN - SCOPUS:85119901407
VL - 162
JO - Neurobiology of Disease
JF - Neurobiology of Disease
SN - 0969-9961
M1 - 105564
ER -