Postsynaptic D1 and D2 dopamine receptors are present in rabbit renal and mesenteric arteries

C. Missale; M. Pizzi; M. Memo; G. B. Picotti; M. O. Carruba; P. F. Spano

doi:10.1016/0304-3940(85)90426-4

Postsynaptic D1 and D2 dopamine receptors are present in rabbit renal and mesenteric arteries

C. Missale, M. Pizzi, M. Memo, G. B. Picotti, M. O. Carruba, P. F. Spano

Istituto di Neuroriabilitazione Motoria San Camillo

Research output: Contribution to journal › Article › peer-review

Abstract

Measuring adenylate cyclase activity as a biochemical index of dopamine (DA) receptors, it was found that the selective D₁ DA receptor agonist, SKF 82526, was able to stimulate the cAMP formation in rabbit renal and mesenteric arteries, an effect blocked by haloperidol and by SCH 23390. The D₂ DA receptor agonist, bromocriptine, elicited a concentration-dependent inhibition of adenylate cyclase activity in both arteries of either normal or 6-hydroxydopamine pretreated rabbits, this effect being prevented by (-)-sulpiride but not by (+)-sulpiride. These data indicate that both D₁ and D₂ postsynaptic DA receptors, associated with stimulation or inhibition of adenylate cyclase activity, are present on the wall of rabbit renal and mesenteric arteries.

Original language	English
Pages (from-to)	207-211
Number of pages	5
Journal	Neuroscience Letters
Volume	61
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(85)90426-4
Publication status	Published - Oct 24 1985

Keywords

6-hydroxydopamine
adenylate cyclase
bromocriptine
mesenteric artery
rabbit
renal artery
SKF 82526

ASJC Scopus subject areas

Neuroscience(all)

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title = "Postsynaptic D1 and D2 dopamine receptors are present in rabbit renal and mesenteric arteries",

abstract = "Measuring adenylate cyclase activity as a biochemical index of dopamine (DA) receptors, it was found that the selective D1 DA receptor agonist, SKF 82526, was able to stimulate the cAMP formation in rabbit renal and mesenteric arteries, an effect blocked by haloperidol and by SCH 23390. The D2 DA receptor agonist, bromocriptine, elicited a concentration-dependent inhibition of adenylate cyclase activity in both arteries of either normal or 6-hydroxydopamine pretreated rabbits, this effect being prevented by (-)-sulpiride but not by (+)-sulpiride. These data indicate that both D1 and D2 postsynaptic DA receptors, associated with stimulation or inhibition of adenylate cyclase activity, are present on the wall of rabbit renal and mesenteric arteries.",

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AU - Missale, C.

AU - Pizzi, M.

AU - Memo, M.

AU - Picotti, G. B.

AU - Carruba, M. O.

AU - Spano, P. F.

PY - 1985/10/24

Y1 - 1985/10/24

N2 - Measuring adenylate cyclase activity as a biochemical index of dopamine (DA) receptors, it was found that the selective D1 DA receptor agonist, SKF 82526, was able to stimulate the cAMP formation in rabbit renal and mesenteric arteries, an effect blocked by haloperidol and by SCH 23390. The D2 DA receptor agonist, bromocriptine, elicited a concentration-dependent inhibition of adenylate cyclase activity in both arteries of either normal or 6-hydroxydopamine pretreated rabbits, this effect being prevented by (-)-sulpiride but not by (+)-sulpiride. These data indicate that both D1 and D2 postsynaptic DA receptors, associated with stimulation or inhibition of adenylate cyclase activity, are present on the wall of rabbit renal and mesenteric arteries.

AB - Measuring adenylate cyclase activity as a biochemical index of dopamine (DA) receptors, it was found that the selective D1 DA receptor agonist, SKF 82526, was able to stimulate the cAMP formation in rabbit renal and mesenteric arteries, an effect blocked by haloperidol and by SCH 23390. The D2 DA receptor agonist, bromocriptine, elicited a concentration-dependent inhibition of adenylate cyclase activity in both arteries of either normal or 6-hydroxydopamine pretreated rabbits, this effect being prevented by (-)-sulpiride but not by (+)-sulpiride. These data indicate that both D1 and D2 postsynaptic DA receptors, associated with stimulation or inhibition of adenylate cyclase activity, are present on the wall of rabbit renal and mesenteric arteries.

KW - 6-hydroxydopamine

KW - adenylate cyclase

KW - bromocriptine

KW - mesenteric artery

KW - rabbit

KW - renal artery

KW - SKF 82526

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Postsynaptic D1 and D2 dopamine receptors are present in rabbit renal and mesenteric arteries

Abstract

Keywords

ASJC Scopus subject areas

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