Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor σL and roles in virulence and in global regulation of gene expression

Elisa Dainese; Sébastien Rodrigue; Giovanni Delogu; Roberta Provvedi; Liette Laflamme; Ryszard Brzezinski; Giovanni Fadda; Issar Smith; Luc Gaudreau; Giorgio Palù; Riccardo Manganelli

doi:10.1128/IAI.74.4.2457-2461.2006

Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor σL and roles in virulence and in global regulation of gene expression

Elisa Dainese, Sébastien Rodrigue, Giovanni Delogu, Roberta Provvedi, Liette Laflamme, Ryszard Brzezinski, Giovanni Fadda, Issar Smith, Luc Gaudreau, Giorgio Palù, Riccardo Manganelli

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.

Original language	English
Pages (from-to)	2457-2461
Number of pages	5
Journal	Infection and Immunity
Volume	74
Issue number	4
DOIs	https://doi.org/10.1128/IAI.74.4.2457-2461.2006
Publication status	Published - Apr 2006

ASJC Scopus subject areas

Immunology

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Dainese, E., Rodrigue, S., Delogu, G., Provvedi, R., Laflamme, L., Brzezinski, R., Fadda, G., Smith, I., Gaudreau, L., Palù, G., & Manganelli, R. (2006). Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor σL and roles in virulence and in global regulation of gene expression. Infection and Immunity, 74(4), 2457-2461. https://doi.org/10.1128/IAI.74.4.2457-2461.2006

Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor σL and roles in virulence and in global regulation of gene expression. / Dainese, Elisa; Rodrigue, Sébastien; Delogu, Giovanni; Provvedi, Roberta; Laflamme, Liette; Brzezinski, Ryszard; Fadda, Giovanni; Smith, Issar; Gaudreau, Luc; Palù, Giorgio; Manganelli, Riccardo.

In: Infection and Immunity, Vol. 74, No. 4, 04.2006, p. 2457-2461.

Research output: Contribution to journal › Article › peer-review

Dainese, E, Rodrigue, S, Delogu, G, Provvedi, R, Laflamme, L, Brzezinski, R, Fadda, G, Smith, I, Gaudreau, L, Palù, G & Manganelli, R 2006, 'Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor σL and roles in virulence and in global regulation of gene expression', Infection and Immunity, vol. 74, no. 4, pp. 2457-2461. https://doi.org/10.1128/IAI.74.4.2457-2461.2006

Dainese, Elisa ; Rodrigue, Sébastien ; Delogu, Giovanni ; Provvedi, Roberta ; Laflamme, Liette ; Brzezinski, Ryszard ; Fadda, Giovanni ; Smith, Issar ; Gaudreau, Luc ; Palù, Giorgio ; Manganelli, Riccardo. / Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor σL and roles in virulence and in global regulation of gene expression. In: Infection and Immunity. 2006 ; Vol. 74, No. 4. pp. 2457-2461.

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