Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor σL and roles in virulence and in global regulation of gene expression

Elisa Dainese, Sébastien Rodrigue, Giovanni Delogu, Roberta Provvedi, Liette Laflamme, Ryszard Brzezinski, Giovanni Fadda, Issar Smith, Luc Gaudreau, Giorgio Palù, Riccardo Manganelli

Research output: Contribution to journalArticle

Abstract

In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.

Original languageEnglish
Pages (from-to)2457-2461
Number of pages5
JournalInfection and Immunity
Volume74
Issue number4
DOIs
Publication statusPublished - Apr 2006

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Sigma Factor
Gene Expression Regulation
Mycobacterium tuberculosis
Virulence
Genes
Infection

ASJC Scopus subject areas

  • Immunology

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Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor σL and roles in virulence and in global regulation of gene expression. / Dainese, Elisa; Rodrigue, Sébastien; Delogu, Giovanni; Provvedi, Roberta; Laflamme, Liette; Brzezinski, Ryszard; Fadda, Giovanni; Smith, Issar; Gaudreau, Luc; Palù, Giorgio; Manganelli, Riccardo.

In: Infection and Immunity, Vol. 74, No. 4, 04.2006, p. 2457-2461.

Research output: Contribution to journalArticle

Dainese, E, Rodrigue, S, Delogu, G, Provvedi, R, Laflamme, L, Brzezinski, R, Fadda, G, Smith, I, Gaudreau, L, Palù, G & Manganelli, R 2006, 'Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor σL and roles in virulence and in global regulation of gene expression', Infection and Immunity, vol. 74, no. 4, pp. 2457-2461. https://doi.org/10.1128/IAI.74.4.2457-2461.2006
Dainese, Elisa ; Rodrigue, Sébastien ; Delogu, Giovanni ; Provvedi, Roberta ; Laflamme, Liette ; Brzezinski, Ryszard ; Fadda, Giovanni ; Smith, Issar ; Gaudreau, Luc ; Palù, Giorgio ; Manganelli, Riccardo. / Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor σL and roles in virulence and in global regulation of gene expression. In: Infection and Immunity. 2006 ; Vol. 74, No. 4. pp. 2457-2461.
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