Abstract
In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.
| Original language | English |
|---|---|
| Pages (from-to) | 2457-2461 |
| Number of pages | 5 |
| Journal | Infection and Immunity |
| Volume | 74 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2006 |
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ASJC Scopus subject areas
- Immunology
Cite this
Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor σL and roles in virulence and in global regulation of gene expression. / Dainese, Elisa; Rodrigue, Sébastien; Delogu, Giovanni; Provvedi, Roberta; Laflamme, Liette; Brzezinski, Ryszard; Fadda, Giovanni; Smith, Issar; Gaudreau, Luc; Palù, Giorgio; Manganelli, Riccardo.
In: Infection and Immunity, Vol. 74, No. 4, 04.2006, p. 2457-2461.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor σL and roles in virulence and in global regulation of gene expression
AU - Dainese, Elisa
AU - Rodrigue, Sébastien
AU - Delogu, Giovanni
AU - Provvedi, Roberta
AU - Laflamme, Liette
AU - Brzezinski, Ryszard
AU - Fadda, Giovanni
AU - Smith, Issar
AU - Gaudreau, Luc
AU - Palù, Giorgio
AU - Manganelli, Riccardo
PY - 2006/4
Y1 - 2006/4
N2 - In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.
AB - In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.
UR - http://www.scopus.com/inward/record.url?scp=33645532080&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645532080&partnerID=8YFLogxK
U2 - 10.1128/IAI.74.4.2457-2461.2006
DO - 10.1128/IAI.74.4.2457-2461.2006
M3 - Article
C2 - 16552079
AN - SCOPUS:33645532080
VL - 74
SP - 2457
EP - 2461
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 4
ER -