TY - JOUR
T1 - Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor σL and roles in virulence and in global regulation of gene expression
AU - Dainese, Elisa
AU - Rodrigue, Sébastien
AU - Delogu, Giovanni
AU - Provvedi, Roberta
AU - Laflamme, Liette
AU - Brzezinski, Ryszard
AU - Fadda, Giovanni
AU - Smith, Issar
AU - Gaudreau, Luc
AU - Palù, Giorgio
AU - Manganelli, Riccardo
PY - 2006/4
Y1 - 2006/4
N2 - In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.
AB - In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.
UR - http://www.scopus.com/inward/record.url?scp=33645532080&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645532080&partnerID=8YFLogxK
U2 - 10.1128/IAI.74.4.2457-2461.2006
DO - 10.1128/IAI.74.4.2457-2461.2006
M3 - Article
C2 - 16552079
AN - SCOPUS:33645532080
VL - 74
SP - 2457
EP - 2461
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 4
ER -