Posttransplant donor-specific antibody characterization and kidney graft survival

A. Piazza, L. Borrelli, P. I. Monaco, E. Poggi, F. Pisani, M. Valeri, D. Fraboni, S. Servetti, C. U. Casciani, D. Adorno

Research output: Contribution to journalArticlepeer-review

Abstract

This study was designed to investigate the clinical relevance of donor-specific antibodies (DS-Abs) and their influence on graft survival. Among 106 patients who underwent cadaveric kidney donor transplantation and were monitored by flow cytometry crossmatch (FCXM) during the 1st posttransplantation year, 25 (23.6%) resulted positive for DS-Ab production. During a 2-year follow up only 12 of the 81 FCXM-negative patients (14.8%) suffered rejection vs 17 of 25 FCXM-positive patients (68%; P = 0.00001). Correlating graft loss to DS-Ab production, 9 FCXM-positive patients lost the graft vs only 1 among the FCXM-negative patients. A worse graft function was evidenced in FCXM-positive subjects who had also suffered rejection episodes than in those which had acute rejection but did not produce DS-Abs. A high incidence of HLA-AB mismatches was found in FCXM-positive subjects which produced anti-class I antibodies. FCXM appears useful in estimating posttransplant alloimmune response. Moreover our findings confirm the harmful effects of anti-class I DS-Abs on long-term graft survival.

Original languageEnglish
JournalTransplant International
Volume13
Issue numberSUPPL. 1
Publication statusPublished - 2000

Keywords

  • Class I histocompatibility antigens immunology
  • Donor-specific antibodies
  • Flow cytometry crossmatch
  • Kidney transplantation immunology
  • Kidney transplantation monitoring

ASJC Scopus subject areas

  • Transplantation

Fingerprint Dive into the research topics of 'Posttransplant donor-specific antibody characterization and kidney graft survival'. Together they form a unique fingerprint.

Cite this