Posttransplant donor-specific antibody characterization and kidney graft survival

A. Piazza, L. Borrelli, P. I. Monaco, E. Poggi, F. Pisani, M. Valeri, D. Fraboni, S. Servetti, C. U. Casciani, D. Adorno

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

This study was designed to investigate the clinical relevance of donor-specific antibodies (DS-Abs) and their influence on graft survival. Among 106 patients who underwent cadaveric kidney donor transplantation and were monitored by flow cytometry crossmatch (FCXM) during the 1st posttransplantation year, 25 (23.6%) resulted positive for DS-Ab production. During a 2-year follow up only 12 of the 81 FCXM-negative patients (14.8%) suffered rejection vs 17 of 25 FCXM-positive patients (68%; P = 0.00001). Correlating graft loss to DS-Ab production, 9 FCXM-positive patients lost the graft vs only 1 among the FCXM-negative patients. A worse graft function was evidenced in FCXM-positive subjects who had also suffered rejection episodes than in those which had acute rejection but did not produce DS-Abs. A high incidence of HLA-AB mismatches was found in FCXM-positive subjects which produced anti-class I antibodies. FCXM appears useful in estimating posttransplant alloimmune response. Moreover our findings confirm the harmful effects of anti-class I DS-Abs on long-term graft survival.

Original languageEnglish
JournalTransplant International
Volume13
Issue numberSUPPL. 1
Publication statusPublished - 2000

Fingerprint

Graft Survival
Tissue Donors
Kidney
Antibodies
Transplants
Immunoglobulin Isotypes
Kidney Transplantation
Flow Cytometry
Incidence

Keywords

  • Class I histocompatibility antigens immunology
  • Donor-specific antibodies
  • Flow cytometry crossmatch
  • Kidney transplantation immunology
  • Kidney transplantation monitoring

ASJC Scopus subject areas

  • Transplantation

Cite this

Piazza, A., Borrelli, L., Monaco, P. I., Poggi, E., Pisani, F., Valeri, M., ... Adorno, D. (2000). Posttransplant donor-specific antibody characterization and kidney graft survival. Transplant International, 13(SUPPL. 1).

Posttransplant donor-specific antibody characterization and kidney graft survival. / Piazza, A.; Borrelli, L.; Monaco, P. I.; Poggi, E.; Pisani, F.; Valeri, M.; Fraboni, D.; Servetti, S.; Casciani, C. U.; Adorno, D.

In: Transplant International, Vol. 13, No. SUPPL. 1, 2000.

Research output: Contribution to journalArticle

Piazza, A, Borrelli, L, Monaco, PI, Poggi, E, Pisani, F, Valeri, M, Fraboni, D, Servetti, S, Casciani, CU & Adorno, D 2000, 'Posttransplant donor-specific antibody characterization and kidney graft survival', Transplant International, vol. 13, no. SUPPL. 1.
Piazza A, Borrelli L, Monaco PI, Poggi E, Pisani F, Valeri M et al. Posttransplant donor-specific antibody characterization and kidney graft survival. Transplant International. 2000;13(SUPPL. 1).
Piazza, A. ; Borrelli, L. ; Monaco, P. I. ; Poggi, E. ; Pisani, F. ; Valeri, M. ; Fraboni, D. ; Servetti, S. ; Casciani, C. U. ; Adorno, D. / Posttransplant donor-specific antibody characterization and kidney graft survival. In: Transplant International. 2000 ; Vol. 13, No. SUPPL. 1.
@article{9f911435ed3c419e99393698d327c848,
title = "Posttransplant donor-specific antibody characterization and kidney graft survival",
abstract = "This study was designed to investigate the clinical relevance of donor-specific antibodies (DS-Abs) and their influence on graft survival. Among 106 patients who underwent cadaveric kidney donor transplantation and were monitored by flow cytometry crossmatch (FCXM) during the 1st posttransplantation year, 25 (23.6{\%}) resulted positive for DS-Ab production. During a 2-year follow up only 12 of the 81 FCXM-negative patients (14.8{\%}) suffered rejection vs 17 of 25 FCXM-positive patients (68{\%}; P = 0.00001). Correlating graft loss to DS-Ab production, 9 FCXM-positive patients lost the graft vs only 1 among the FCXM-negative patients. A worse graft function was evidenced in FCXM-positive subjects who had also suffered rejection episodes than in those which had acute rejection but did not produce DS-Abs. A high incidence of HLA-AB mismatches was found in FCXM-positive subjects which produced anti-class I antibodies. FCXM appears useful in estimating posttransplant alloimmune response. Moreover our findings confirm the harmful effects of anti-class I DS-Abs on long-term graft survival.",
keywords = "Class I histocompatibility antigens immunology, Donor-specific antibodies, Flow cytometry crossmatch, Kidney transplantation immunology, Kidney transplantation monitoring",
author = "A. Piazza and L. Borrelli and Monaco, {P. I.} and E. Poggi and F. Pisani and M. Valeri and D. Fraboni and S. Servetti and Casciani, {C. U.} and D. Adorno",
year = "2000",
language = "English",
volume = "13",
journal = "Transplant International",
issn = "0934-0874",
publisher = "Blackwell Publishing Ltd",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Posttransplant donor-specific antibody characterization and kidney graft survival

AU - Piazza, A.

AU - Borrelli, L.

AU - Monaco, P. I.

AU - Poggi, E.

AU - Pisani, F.

AU - Valeri, M.

AU - Fraboni, D.

AU - Servetti, S.

AU - Casciani, C. U.

AU - Adorno, D.

PY - 2000

Y1 - 2000

N2 - This study was designed to investigate the clinical relevance of donor-specific antibodies (DS-Abs) and their influence on graft survival. Among 106 patients who underwent cadaveric kidney donor transplantation and were monitored by flow cytometry crossmatch (FCXM) during the 1st posttransplantation year, 25 (23.6%) resulted positive for DS-Ab production. During a 2-year follow up only 12 of the 81 FCXM-negative patients (14.8%) suffered rejection vs 17 of 25 FCXM-positive patients (68%; P = 0.00001). Correlating graft loss to DS-Ab production, 9 FCXM-positive patients lost the graft vs only 1 among the FCXM-negative patients. A worse graft function was evidenced in FCXM-positive subjects who had also suffered rejection episodes than in those which had acute rejection but did not produce DS-Abs. A high incidence of HLA-AB mismatches was found in FCXM-positive subjects which produced anti-class I antibodies. FCXM appears useful in estimating posttransplant alloimmune response. Moreover our findings confirm the harmful effects of anti-class I DS-Abs on long-term graft survival.

AB - This study was designed to investigate the clinical relevance of donor-specific antibodies (DS-Abs) and their influence on graft survival. Among 106 patients who underwent cadaveric kidney donor transplantation and were monitored by flow cytometry crossmatch (FCXM) during the 1st posttransplantation year, 25 (23.6%) resulted positive for DS-Ab production. During a 2-year follow up only 12 of the 81 FCXM-negative patients (14.8%) suffered rejection vs 17 of 25 FCXM-positive patients (68%; P = 0.00001). Correlating graft loss to DS-Ab production, 9 FCXM-positive patients lost the graft vs only 1 among the FCXM-negative patients. A worse graft function was evidenced in FCXM-positive subjects who had also suffered rejection episodes than in those which had acute rejection but did not produce DS-Abs. A high incidence of HLA-AB mismatches was found in FCXM-positive subjects which produced anti-class I antibodies. FCXM appears useful in estimating posttransplant alloimmune response. Moreover our findings confirm the harmful effects of anti-class I DS-Abs on long-term graft survival.

KW - Class I histocompatibility antigens immunology

KW - Donor-specific antibodies

KW - Flow cytometry crossmatch

KW - Kidney transplantation immunology

KW - Kidney transplantation monitoring

UR - http://www.scopus.com/inward/record.url?scp=0005635728&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0005635728&partnerID=8YFLogxK

M3 - Article

C2 - 11112049

AN - SCOPUS:0005635728

VL - 13

JO - Transplant International

JF - Transplant International

SN - 0934-0874

IS - SUPPL. 1

ER -