Posttransplantation cutaneous B-cell lymphoma with monoclonal epstein- barr virus infection, responding to acyclovir and reduction in immunosuppression

N. Mozzanica, A. Cattaneo, N. Fracchiolla, V. Boneschi, E. Berti, E. Gronda, M. Mangiavacchi, A. F. Finzi, A. Neri

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Posttransplantation lymphoproliferative disorders (PTLDs) represent an important complication of solid organ transplantation. The main causative factor of PTLDs seems to be the intensity and type of immunosuppressive therapy and the frequent occurrence of Epstein-Barr virus infection. PTLDs that are disseminated at diagnosis or present late after transplantation generally share an unfavorable prognosis and are unlikely to regress in response to reduction in immunosuppressive therapy. We describe a case of cutaneous B-cell lymphoma occurring 4 years after heart transplantation in which molecular analysis revealed a monoclonal pattern of Epstein-Barr virus infection and immunoglobulin gene rearrangement. In spite of its monoclonal nature and late occurrence, the lymphomatous lesions regressed completely after antiviral treatment and a reduction in immunosuppressive therapy.

Original languageEnglish
Pages (from-to)964-968
Number of pages5
JournalJournal of Heart and Lung Transplantation
Volume16
Issue number9
Publication statusPublished - 1997

Fingerprint

Epstein-Barr Virus Infections
Acyclovir
B-Cell Lymphoma
Immunosuppression
Lymphoproliferative Disorders
Immunosuppressive Agents
Skin
Immunoglobulin Genes
Gene Rearrangement
Organ Transplantation
Heart Transplantation
Therapeutics
Antiviral Agents
Transplantation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Transplantation

Cite this

@article{ae887ec96f984f4a8971f96ee724ab54,
title = "Posttransplantation cutaneous B-cell lymphoma with monoclonal epstein- barr virus infection, responding to acyclovir and reduction in immunosuppression",
abstract = "Posttransplantation lymphoproliferative disorders (PTLDs) represent an important complication of solid organ transplantation. The main causative factor of PTLDs seems to be the intensity and type of immunosuppressive therapy and the frequent occurrence of Epstein-Barr virus infection. PTLDs that are disseminated at diagnosis or present late after transplantation generally share an unfavorable prognosis and are unlikely to regress in response to reduction in immunosuppressive therapy. We describe a case of cutaneous B-cell lymphoma occurring 4 years after heart transplantation in which molecular analysis revealed a monoclonal pattern of Epstein-Barr virus infection and immunoglobulin gene rearrangement. In spite of its monoclonal nature and late occurrence, the lymphomatous lesions regressed completely after antiviral treatment and a reduction in immunosuppressive therapy.",
author = "N. Mozzanica and A. Cattaneo and N. Fracchiolla and V. Boneschi and E. Berti and E. Gronda and M. Mangiavacchi and Finzi, {A. F.} and A. Neri",
year = "1997",
language = "English",
volume = "16",
pages = "964--968",
journal = "Journal of Heart and Lung Transplantation",
issn = "1053-2498",
publisher = "Elsevier USA",
number = "9",

}

TY - JOUR

T1 - Posttransplantation cutaneous B-cell lymphoma with monoclonal epstein- barr virus infection, responding to acyclovir and reduction in immunosuppression

AU - Mozzanica, N.

AU - Cattaneo, A.

AU - Fracchiolla, N.

AU - Boneschi, V.

AU - Berti, E.

AU - Gronda, E.

AU - Mangiavacchi, M.

AU - Finzi, A. F.

AU - Neri, A.

PY - 1997

Y1 - 1997

N2 - Posttransplantation lymphoproliferative disorders (PTLDs) represent an important complication of solid organ transplantation. The main causative factor of PTLDs seems to be the intensity and type of immunosuppressive therapy and the frequent occurrence of Epstein-Barr virus infection. PTLDs that are disseminated at diagnosis or present late after transplantation generally share an unfavorable prognosis and are unlikely to regress in response to reduction in immunosuppressive therapy. We describe a case of cutaneous B-cell lymphoma occurring 4 years after heart transplantation in which molecular analysis revealed a monoclonal pattern of Epstein-Barr virus infection and immunoglobulin gene rearrangement. In spite of its monoclonal nature and late occurrence, the lymphomatous lesions regressed completely after antiviral treatment and a reduction in immunosuppressive therapy.

AB - Posttransplantation lymphoproliferative disorders (PTLDs) represent an important complication of solid organ transplantation. The main causative factor of PTLDs seems to be the intensity and type of immunosuppressive therapy and the frequent occurrence of Epstein-Barr virus infection. PTLDs that are disseminated at diagnosis or present late after transplantation generally share an unfavorable prognosis and are unlikely to regress in response to reduction in immunosuppressive therapy. We describe a case of cutaneous B-cell lymphoma occurring 4 years after heart transplantation in which molecular analysis revealed a monoclonal pattern of Epstein-Barr virus infection and immunoglobulin gene rearrangement. In spite of its monoclonal nature and late occurrence, the lymphomatous lesions regressed completely after antiviral treatment and a reduction in immunosuppressive therapy.

UR - http://www.scopus.com/inward/record.url?scp=0030886347&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030886347&partnerID=8YFLogxK

M3 - Article

C2 - 9322148

AN - SCOPUS:0030886347

VL - 16

SP - 964

EP - 968

JO - Journal of Heart and Lung Transplantation

JF - Journal of Heart and Lung Transplantation

SN - 1053-2498

IS - 9

ER -