Posttransplantation lymphoproliferative disorders

Pietro Andreone, Annagiulia Gramenzi, Stefania Lorenzini, Maurizio Biselli, Carmela Cursaro, Stefano Pileri, Mauro Bernardi

Research output: Contribution to journalArticle

Abstract

Posttransplantation lymphoproliferative disorders include a wide spectrum of diseases ranging from hyperplastic-appearing lesions to frank non-Hodgkin lymphoma. More than 90% of these disorders are Epstein-Barr virus-associated lesions of B-cell origin that arise in the setting of pharmacologic immunosuppression after transplantation. With the increased use of organ transplantation and intensive immunosuppression, posttransplantation lymphoproliferative disorders are becoming more common. The prognosis is often poor, with most patients dying despite receiving treatment. The aim of this review is to report the most recent knowledge about the clinical features, diagnosis, prophylaxis, and treatment of posttransplantation lymphoproliferative disorders, which can be useful to physicians and health assistants dealing with these life-threatening, posttransplantation clinical entities in clinical practice.

Original languageEnglish
Pages (from-to)1997-2004
Number of pages8
JournalArchives of Internal Medicine
Volume163
Issue number17
DOIs
Publication statusPublished - Sep 22 2003

ASJC Scopus subject areas

  • Internal Medicine

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    Andreone, P., Gramenzi, A., Lorenzini, S., Biselli, M., Cursaro, C., Pileri, S., & Bernardi, M. (2003). Posttransplantation lymphoproliferative disorders. Archives of Internal Medicine, 163(17), 1997-2004. https://doi.org/10.1001/archinte.163.17.1997