Posttraumatic growth, immunity and survival in patients with hepatoma

James T. Dunigan, Brian I. Carr, Jennifer L. Steel

Research output: Contribution to journalArticlepeer-review

Abstract

This study was designed to assess the relationship between posttraumatic growth (PTG), immunity, and survival in patients with biopsy-proven hepatocellular carcinoma (HCC). Forty-one patients with HCC were administered the Posttraumatic Growth Inventory. Total and differential peripheral blood leukocytes (PBL) counts were measured at baseline, 3-, and 6-month follow-up. Survival also was measured from the data of diagnosis to death. Participants who scored above the median for the PTGI total scale score (423 days) survived 186 days longer than participants who scored below the median PTGI total score (237 days). Patients with PTG scores above the median had higher PBL counts. The results of this study suggest that patients with greater PTG scores recover more rapidly from chemotherapy in regards to their white blood cell counts. Further research is warranted regarding the possible immune mediation between PTG and survival.

Original languageEnglish
Pages (from-to)2452-2459
Number of pages8
JournalDigestive Diseases and Sciences
Volume52
Issue number9
DOIs
Publication statusPublished - Sep 2007

Keywords

  • Hepatocellular carcinoma
  • HPA-axis
  • Immune system functioning
  • Posttraumatic growth

ASJC Scopus subject areas

  • Gastroenterology

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