Postural Control in Patients After a Recent Vestibular Neuritis with Hyperhomocysteinemia

G. Raponi, R. Teggi, O. Gatti, L. Giordano, M. Bussi

Research output: Contribution to journalArticlepeer-review

Abstract

To assess the possible role of hyperhomocysteinemia (HyHcy) in delaying recovery after acute vestibular neuritis. In our retrospective study, 90 subjects were evaluated within 7 days from the beginning of an acute vertigo. All subjects had high plasma levels of homocysteine (Hcy). 46 patients were treated with homocysteine lowering therapy and betahistine for 1 month, while 44 subjects received only betahistine. Subjective symptoms were evaluated with the Dizziness Handicap Inventory (DHI) questionnaire, administered 7 days after the beginning of vertigo and again after 1 month. Moreover, postural control performed at 1 month' control was studied with static stabilometry in a subgroup of 21 non-treated and 20 treated patients. DHI total score decreased significantly more in the subgroup of subjects treated with homocysteine lowering therapy. Moreover, posturographic data were significantly increased in non-treated compared with treated subjects. Our data support the possibility of a role of HyHcy in preventing recovery after a recent vestibular neuritis. A microvascular disorder or the neurotoxic effect of HyHcy have been considered as possible causal factors. Although not conclusive, our data are not inconsistent with the hypothesis of a poorer adaptation in patients with untreated HyHcy.

Original languageEnglish
Pages (from-to)146-150
Number of pages5
JournalIndian Journal of Otolaryngology and Head and Neck Surgery
Volume65
Issue number2
DOIs
Publication statusPublished - Apr 2013

Keywords

  • Hyperhomocysteinemia
  • Static stabilometry
  • Vestibular adaptation
  • Vestibular neuritis

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery

Fingerprint Dive into the research topics of 'Postural Control in Patients After a Recent Vestibular Neuritis with Hyperhomocysteinemia'. Together they form a unique fingerprint.

Cite this