Postural stabilization and balance assessment in Charcot-Marie-Tooth 1A subjects

Research output: Contribution to journalArticle

Abstract

The aim of the present study was to assess postural stabilization skill in adult subjects affected by Charcot-Marie-Tooth disease (CMT) type 1A. For this purpose ground reaction force (GRF) was measured by means of a piezoelectric force platform during the sit-to-stand (STS) movement, until a steady state erect posture was achieved. Specific indexes to quantify Centre of Mass acceleration, both during postural stabilization and during quiet standing, were computed using a mathematical model. Forty-seven CMT1A subjects were recruited for the study, and the control group was formed by forty-one age- and sex-matched healthy subjects.The results show that CMT1A subjects are less stable than controls during the quiet stance. Greater difficulty (high values of Yinf, the final instability rate) to maintain erect posture appears to be mainly associated with plantar-flexor muscle weakness, rather than to damage of the proprioceptive system. The worst performances shown by CMT1A subjects in the stabilization phase (high values of I, the global index of postural stabilization performance) seem to be associated with reduced muscle strength and the loss of large sensory nerve fibres.Distal muscle weakness appears to affect both postural stabilization and quiet erect posture. The presented protocol and the analysis of postural stabilization parameters provide useful information on CMT1A balance disorders.

Original languageEnglish
Pages (from-to)481-486
Number of pages6
JournalGait and Posture
Volume40
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

Postural Balance
Posture
Tooth
Muscle Weakness
Charcot-Marie-Tooth Disease
Muscle Strength
Nerve Fibers
Healthy Volunteers
Theoretical Models
Control Groups

Keywords

  • Balance
  • Charcot-Marie-Tooth
  • Muscle strength
  • Plantar flexion
  • Posture

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Rehabilitation
  • Biophysics
  • Medicine(all)

Cite this

Postural stabilization and balance assessment in Charcot-Marie-Tooth 1A subjects. / Lencioni, T.; Rabuffetti, M.; Piscosquito, G.; Pareyson, D.; Aiello, A.; Di Sipio, E.; Padua, L.; Stra, F.; Ferrarin, M.

In: Gait and Posture, Vol. 40, No. 4, 2014, p. 481-486.

Research output: Contribution to journalArticle

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