Postural strategies in Prader-Willi and Down syndrome patients

Veronica Cimolin, Manuela Galli, Graziano Grugni, Luca Vismara, Helmer Precilios, Giorgio Albertini, Chiara Rigoldi, Paolo Capodaglio

Research output: Contribution to journalArticlepeer-review


Patients affected by Down (DS) and Prader-Willi syndrome (PWS) are characterised by some common clinical and functional features including gait disorders and reduced postural control. The aim of our study was to quantitatively compare postural control in adult PWS and DS.We studied 12 PWS and 19 DS adult patients matched for age, height, weight and body mass index.They were instructed to maintain an upright standing position on a force platform for 30s with open eyes (OE) and we calculated the range of center of pressure (CoP) displacement in the A/P direction (RANGEAP) and in the M/L direction (RANGEML) and the total CoP trajectory length during quiet stance (Sway Path, SP).The range of oscillations in PWS and DS in both AP and ML direction were higher than in controls. PWS and DS were statistically different for RANGEAP, with PWS showing higher mean values.Our results confirm a reduced capacity of both PWS and DS in maintaining postural stability. This appears to be in some respect different in PWS and DS, with PWS showing poorer control in AP. DS and, particularly, PWS should be encouraged to undergo specific balance training and strengthening of the ankle muscles as part of a comprehensive rehabilitation program to enhance daily functioning and quality of life.

Original languageEnglish
Pages (from-to)669-673
Number of pages5
JournalResearch in Developmental Disabilities
Issue number2
Publication statusPublished - Mar 2011


  • Down syndrome
  • Posture
  • Prader-Willi syndrome
  • Rehabilitation

ASJC Scopus subject areas

  • Clinical Psychology
  • Developmental and Educational Psychology


Dive into the research topics of 'Postural strategies in Prader-Willi and Down syndrome patients'. Together they form a unique fingerprint.

Cite this