Potassium currents in rat cortical neurons in culture are enhanced by the antiepileptic drug carbamazepine

C. Zona, V. Tancredi, E. Palma, G. C. Pirrone, M. Avoli

Research output: Contribution to journalArticle

Abstract

We report that carbamazepine (Tegretol), a drug that is useful for the treatment of complex partial seizures, enhances outward, voltage-dependent K+ currents generated by rat neocortical cells in culture and recorded with patch-clamping techniques. This effect is seen in the presence of therapeutic concentrations of carbamazepine (10-20 μM). Furthermore, at these doses carbamazepine does not influence voltage-dependent inward Na+ and Ca2+ currents recorded in these cells. The action exerted by carbamazepine on K+ currents is a novel finding and might represent an important mechanism for controlling neocortical excitability and thus the generation of epileptiform activity.

Original languageEnglish
Pages (from-to)545-547
Number of pages3
JournalCanadian Journal of Physiology and Pharmacology
Volume68
Issue number4
Publication statusPublished - 1990

Keywords

  • antiepileptic drugs
  • carbamazepine
  • potassium currents
  • rat neocortex

ASJC Scopus subject areas

  • Physiology
  • Pharmacology

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